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Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes.
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These studies provide strong evidence for a pathophysiological link between meprin beta and urinary excretion of cleaved nidogen-1 during cisplatin-induced acute kidney injury.
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The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation.
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nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels.
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finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions
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show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
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Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
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This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity.
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Results suggest a non-structural role for nidogen 1 in wound repair.
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short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2
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Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.
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These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized.
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Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene.
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structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5)
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Expression may promote formation of sinusoids after partial hepatectomy.
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Laminin gamma3 chain, located in murine basement membranes, binds to nidogen
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Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue
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nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone
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nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud
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expression of the entactin-1 dramatically declined in myogenesis