anti-Nidogen 1 (NID1) Antibodies

Zebrafish Nidogen 1 (NID1) interaction partners

1. Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish

Mouse (Murine) Nidogen 1 (NID1) interaction partners

1. Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes.

2. These studies provide strong evidence for a pathophysiological link between meprin beta and urinary excretion of cleaved nidogen-1 during cisplatin-induced acute kidney injury.

3. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation.

4. nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels.

5. finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions

6. show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane

7. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.

8. This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity.

9. Results suggest a non-structural role for nidogen 1 in wound repair.

10. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2

11. Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.

12. These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized.

13. Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene.

14. structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5)

15. Expression may promote formation of sinusoids after partial hepatectomy.

16. Laminin gamma3 chain, located in murine basement membranes, binds to nidogen

17. Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue

18. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone

19. nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud

20. expression of the entactin-1 dramatically declined in myogenesis

Human Nidogen 1 (NID1) interaction partners

1. With the demonstration of the anti-migratory effect of endothelial cell-derived nidogen-1 on SK-BR-3 breast cancer cells study adds nidogen-1 to the regulators of endothelial control over cancer cell migration.

2. Results demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The study presents evidence that NID1 promotes the migration, invasion and chemoresistance of ovarian cancer cells via EMT and its molecular mechanism involves the activation of ERK/MAPK signaling.

3. Nidogen 1 (NID1) was confirmed to promote lung metastasis of breast cancer and melanoma.

4. nidogen-1 degraded by CatS can be quantified in serum by the NIC assay. The current data strongly suggest that cathepsin-S degradation of nidogen-1 is strongly associated with NSCLC, which needs validation in larger clinical cohorts.

5. Differential protein expression of collagen IV, laminin alpha2, and nidogen-1 indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts.

6. NID1 was confirmed as a target gene of MiR-192/215 in Hirschsprung's disease patients.

7. Increase of NID1 protein expression is associated with endometrial cancer invasion.

8. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples.

9. results demonstrate that mutation in either NID1 or LAMC1 disrupts the interaction NID1-LAMC1 complex; findings implicate the extracellular matrix in the pathogenesis of Dandy-Walker spectrum disorders

10. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners

11. NID1 gene is a biologically plausible locus for nevogenesis and melanoma development

12. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development

13. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone

14. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines.