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E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping NSMCE2 Proteins (8) and NSMCE2 Kits (2) and many more products for this protein.
Showing 10 out of 81 products:
Human Polyclonal NSMCE2 Primary Antibody for IF, WB - ABIN531598
Chung, Leonhardt, Rippe: De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation. in Journal of cell science 2011
Show all 2 Pubmed References
Human Polyclonal NSMCE2 Primary Antibody for ELISA, IHC - ABIN4340745
Verver, Zheng, Speijer, Hoebe, Dekker, Repping, Stap, Hamer: Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. in International journal of molecular sciences 2016
SUMO- and BLM (show BLM Antibodies)-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation.
Absence of NSMCE2 affects survival upon topoisomerase II (show TOP2 Antibodies) inhibitor etoposide-induced DNA double-strand breaks double-strand breaks.
our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia.
support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress
show that the Smc5 (show SMC5 Antibodies)/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1 (show PTPRJ Antibodies)
Studies indicate that Nse1 (show FAM84A Antibodies) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5 (show SMC5 Antibodies)/6 complex.
the human SMC5 (show SMC5 Antibodies)/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells
MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6 (show SMC6 Antibodies).
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).
E3 SUMO-protein ligase NSE2
, MMS21 homolog
, non-structural maintenance of chromosomes element 2 homolog
, non-SMC element 2 homolog
, methyl methanesulfonate sensitivity gene 21
, zinc finger, MIZ-type containing 7
, non-SMC element 2 homolog (MMS21, S. cerevisiae)
, Non-structural maintenance of chromosomes element 2