Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) ELISA Kits

NFE2L1 encodes a protein that is involved in globin gene expression in erythrocytes. Additionally we are shipping NFE2L1 Antibodies (70) and NFE2L1 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NFE2L1 4779 Q14494
NFE2L1 18023 Q61985
Anti-Rat NFE2L1 NFE2L1 360610  
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Top NFE2L1 ELISA Kits at

Showing 4 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 35 pg/mL 78-5000 pg/mL   96 Tests 2 to 3 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for NFE2L1 Interaction Partners

Human Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) interaction partners

  1. study identified O-linked N-acetylglucosamine transferase (OGT) and host cell factor C1 (HCF-1) as two proteins capable of forming a complex with NRF1. O-GlcNAcylation catalyzed by OGT was essential for NRF1 stabilization and consequent upregulation of proteasome subunit genes

  2. Here, we tested the hypothesis that calpain-1 or -2 cleave TCF11/Nrf1. However, we did not find a role for calpain-1 or -2 in the activation of TCF11/Nrf1 after proteasome inhibition neither by using chemical inhibitors nor siRNA-mediated knockdown or overexpression of calpain subunits

  3. These findings indicate that NFE2L1(L) functions as a negative regulator of M1 polarization and pro-inflammatory response in macrophages

  4. The nascent Nrf1alpha (NFE2L1)/TCF11 polypeptide (non-glycosylated) is transiently translocated into the endoplasmic reticulum (ER).

  5. Low nuclear expression of Nrf1, high cytoplasmic expression of Nrf1, high nuclear expression of Nrf2 and low cytoplasmic expression of Keap1 are associated with adverse outcome in high-risk diffuse large B cell lymphomas treated with R-CHOEP

  6. Data show that Nrf1 can adopt several topologies within membranes that are determined by its NTD.

  7. Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.

  8. results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin

  9. Data indicate both Nrf1a and Nrf1b isoforms transcripts were detected in different mouse and human cell lines, and in various mouse tissues.

  10. Nrf1 knockout resulted in the increased expression of GCLC and GCLM in human bronchial epithelial (HBE1) cells.

  11. while Nrf2 is crucial for MRE/ARE-mediated transcription in response to copper, Nrf1 may activate MT-1 expression by a mechanism different from that Nrf2 employs.

  12. Nrf1 physically interacts with androgen receptor and enhances it's DNA-binding activity, suggesting that the p65-Nrf1 isoform is a potential androgen receptor coactivator.

  13. The treatment with E2, Res, or VC significantly increased mRNA and protein expression levels of Nrf1.

  14. The results indicate that Nrf1 is a transcriptional activator of Herpud1 expression during ER stress, and they suggest Nrf1 is a key player in the regulation of the ER stress response in cells.

  15. This review outlines Nrf1 structure, function, regulation and its links to insulin resistance, diabetes and inflammation.

  16. Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors

  17. Together with molecular expression results, the authors thus suppose requirement of Nrf1alpha (and major derivates) for gene regulatory mechanisms repressing cancer cell process and malignant behaviour.

  18. These results uncover a new regulatory mechanism that USP15 activates Nrf1 against the beta-TrCP inhibition to maintain proteostasis.

  19. Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1.

  20. Nrf1 is regulated by O-GlcNAc transferase.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) interaction partners

  1. findings reveal novel functions of the NGLY1-NRF1 (Nfe2l1) pathway in mitochondrial homeostasis and inflammation and uncover an unexpected therapeutic strategy using pharmacological activators of NRF2 for treating mitochondrial and immune dysregulation

  2. Nrf1, RUVBL1, and TIP60 proteins were co-recruited to the promoter regions of proteasome genes after proteasome inhibitor treatments.

  3. Nrf1 (Nfe2l1) emerges as a novel guardian of brown adipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity.

  4. These findings indicate that NFE2L1(L) functions as a negative regulator of M1 polarization and pro-inflammatory response in macrophages

  5. Putative ubiquitination of Nrf1 (Nf2el1) is not a prerequisite necessary for involvement of p97 in the client processing.

  6. The nascent Nrf1alpha (NFE2L1)/TCF11 polypeptide (non-glycosylated) is transiently translocated into the endoplasmic reticulum (ER).

  7. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance.

  8. our investigation shows that the ER membrane protein TCF11/Nrf1 is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.

  9. Deficiency of long isoforms of Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.

  10. Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations

  11. Denervation induced proteasomal activation via NFE2L1 nuclear translocation in control mice

  12. This stduy identify the bZIP transcription factor Nfe2l1 and demonstrate that it promotes glial fate under direct Sox9 regulatory control.

  13. The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes.

  14. Nrf1 plays an integral role in the maintenance of proteasome function in hepatocytes and in the prevention of liver steatosis development.

  15. findings suggest that nuclear-related factor erythroid 2 transcription factor (Nrf1) may play a role in maintaining genomic integrity, and that Nrf1 dysregulation may induce tumorigenesis

  16. The transcription factor, TCF11, is at the crossroads of oxidative stress and the ubiquitin proteasome system.

  17. Data show that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts.

  18. the first in vivo experimental evidence that NFE2L1 produced by osteoblasts is involved in regulating osterix expression, osteoblast differentiation, and bone formation

  19. may promote cell survival by maintaining redox balance and protecting embryonic hepatocytes from TNF-mediated apoptosis during development

  20. the physical interaction between Nrf1 and C/EBPbeta provide a novel mechanism for the transcriptional regulation of DSPP in odontoblasts.

NFE2L1 Antigen Profile

Antigen Summary

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1.

Gene names and symbols associated with NFE2L1

  • nuclear factor, erythroid 2 like 1 (NFE2L1) antibody
  • nuclear factor, erythroid derived 2,-like 1 (Nfe2l1) antibody
  • nuclear factor, erythroid 2-like 1 (Nfe2l1) antibody
  • nuclear factor, erythroid 2 like 1 (Nfe2l1) antibody
  • nuclear factor, erythroid 2 like 1 S homeolog (nfe2l1.S) antibody
  • nuclear factor, erythroid 2-like 1a (nfe2l1a) antibody
  • AA408798 antibody
  • AW212678 antibody
  • LCR-F1 antibody
  • Lcrf1 antibody
  • nfe2l1 antibody
  • NRF1 antibody
  • TCF-11 antibody
  • TCF11 antibody

Protein level used designations for NFE2L1

NF-E2-related factor 1 , NFE2-related factor 1 , TCF-11 , locus control region-factor 1 , nuclear factor (erythroid-derived 2)-like 1 , nuclear factor erythroid 2-related factor 1 , nuclear factor, erythroid derived 2, like 1 , transcription factor 11 (basic leucine zipper type) , transcription factor HBZ17 , transcription factor LCR-F1 , nuclear factor erythroid 2-like 1 , nuclear factor, erythroid 2 like 1 S homeolog , nuclear factor, erythroid 2-like 1 , nrf1a , nuclear factor, erythroid derived 2,-like 1 , nuclear factor, erythroid derived 2,-like 1a , nuclear factor-like 1 , nuclear factor-like 1a protein

4779 Homo sapiens
18023 Mus musculus
360610 Rattus norvegicus
417987 Gallus gallus
534582 Bos taurus
100172747 Pongo abelii
100716712 Cavia porcellus
379703 Xenopus laevis
405781 Danio rerio
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