Nuclear Protein, Transcriptional Regulator, 1 Proteins (NUPR1)

Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. Additionally we are shipping Nuclear Protein, Transcriptional Regulator, 1 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NUPR1 26471 O60356
NUPR1 56312 Q9WTK0
NUPR1 100912108 O54842;
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Top Nuclear Protein, Transcriptional Regulator, 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,113.83
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NUPR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Protein, Transcriptional Regulator, 1 (NUPR1) Interaction Partners

Human Nuclear Protein, Transcriptional Regulator, 1 (NUPR1) interaction partners

  1. NUPR1 regulates the late stages of autolysosome processing through the induction of the SNARE protein SNAP25

  2. High NUPR1 expression is associated with multiple myeloma.

  3. Knockdown of nuclear protein-1 inhibits the proliferation of humans glioblastoma cells via ERK1/2, p38 MAPK and caspase-3.

  4. dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1/FGF21 axis

  5. NUPR1/RELB/IER3/RUNX2 pathway has a pivotal role in hepatocarcinogenesis.

  6. Hexavalent Cr(VI) induces Nupr1 and rapidly perturbs gene expression by downregulating H4K16 acetylation, thereby contributing to Cr(VI)-induced carcinogenesis.

  7. findings suggest that local interactions and hydrophobic effects play a major role in determining the electrostatic features of NUPR1, whereas long-range charge contributions appear to be of lesser importance.

  8. Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 expression and consequently genome-wide levels of DNA methylation.

  9. Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.

  10. Mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1-granulin pathway, play pivotal roles in liver cancer progression

  11. Functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.

  12. Knockdown of Nupr1 inhibited the proliferation and migration of HepG2 hepatocellular carcinoma cells

  13. NUPR1 has been conserved throughout evolution, and over time it has undergone duplications and transpositions to form other transcriptional regulators.

  14. Increase of NUPR1 protein expression is associated with endometrial cancer invasion.

  15. P8 and MEG3 mRNA levels were significantly lower in nonfunctioning and corticotroph adenomas compared with normal pituitary.

  16. The Nupr1 protein bound to chemically-damaged-DNA with a slightly larger affinity (0.4 microM), but in an enthalpically-driven process. Nupr1 showed different interacting regions in the formed complexes with Nupr1 or DNA

  17. Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.

  18. COM1 is a potential tumour suppressor in human bladder cancer.

  19. NUPR1 negatively regulates autophagy-mediated cell death via AURKA, in line with the idea of a tumor suppressor role of autophagy in cancer.

  20. The simultaneous gain of NUPR1 and ERBB2 can be a significant predictor of poor prognosis in early-stage breast cancers.

Mouse (Murine) Nuclear Protein, Transcriptional Regulator, 1 (NUPR1) interaction partners

  1. p8 depletion may contribute to glucose metabolism via stress-induced insulin production and elevated beta cell mass. Nevertheless, p8 knockout showed no impact on insulin resistance in standard and high-fat diet-fed mice.

  2. Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 expression and consequently genome-wide levels of DNA methylation.

  3. Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.

  4. Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity.

  5. p8 has no impact on the cellular composition of the adaptive and innate immune systems in noninflammatory conditions. However, it may limit apoptosis and maintain homeostasis of the immune reaction during acute pancreatitis.

  6. Nupr1 aids oncogenic Kras to bypass senescence in a manner that cooperatively promotes pancreas intraepithelial neoplasia formation.

  7. data shows that p8 deficiency increases ROS and subsequently the expression of anti-oxidative enzymes, such as HO-1, suggesting an involvement in the anti-oxidative defense.

  8. According to Nupr1 status, KIC mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.

  9. Nupr1 expression is required for IL-1beta-mediated expression of MMP-13.

  10. Inhibition of NUPR1 expression or activity has the potential to protect against the metabolic defects associated with obesity and type 2 diabetes.

  11. a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic Kras(G12D)-dependent transformation of the pancreas.

  12. progressive PPARalpha- and p8-mediated ER stress contribute to the hepatocarcinogenesis in ACOX1(-/-) mice

  13. p8-deletion resulted in reduced collagen fibrosis after transverse aortic constriction, but in turn, was associated with a detrimental higher increase in autophagy.

  14. amino acid starvation was able to induce p8 expression; GCN2/ATF4 pathway is involved in this regulation through the presence of an Amino Acid Response Element in p8 promoter.

  15. A role for the transcriptional regulator p8 in autophagy, is demonstrated.

  16. P8 is a growth inhibitor that facilitates apoptosis induced in fibroblasts by DNA damage

  17. improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I

  18. Maintenance of the transformed phenotype of pituitary GH3 cells requires expression of p8 and that it may play a similar role when reexpressed in a subset of lactotropes that form prolactinomas in vivo.

  19. p8 is an excellent candidate as a novel biomarker of demyelination

  20. TNFalpha-induced NF kappaB pathway contributes to the induction of p8 during pancreatitis and lipopolysaccharide-induced inflammation.

Nuclear Protein, Transcriptional Regulator, 1 (NUPR1) Protein Profile

Protein Summary

Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype.

Gene names and symbols associated with NUPR1

  • nuclear protein 1, transcriptional regulator (NUPR1)
  • nuclear protein transcription regulator 1 (Nupr1)
  • nuclear protein 1, transcriptional regulator (Nupr1)
  • 2310032H04Rik protein
  • Com1 protein
  • p8 protein

Protein level used designations for NUPR1

candidate of metastasis 1 , nuclear protein 1 , protein p8 , p8 protein , nuclear protein, transcriptional regulator, 1 , Candidate of metastasis 1 , Nuclear transcriptional regulator protein 1 , Protein p8 , nuclear protein 1-like , nuclear proten 1 , nuclear transcriptional regulator protein 1

GENE ID SPECIES
26471 Homo sapiens
56312 Mus musculus
614673 Bos taurus
479793 Canis lupus familiaris
102146652 Macaca fascicularis
100912108 Rattus norvegicus
100064252 Equus caballus
100343968 Oryctolagus cuniculus
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