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Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. Additionally we are shipping Nuclear Protein, Transcriptional Regulator, 1 Antibodies (57) and many more products for this protein.
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High NUPR1 expression is associated with multiple myeloma.
Knockdown of nuclear protein-1 inhibits the proliferation of humans glioblastoma cells via ERK1/2, p38 MAPK (show MAPK14 Proteins) and caspase-3 (show CASP3 Proteins).
dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1/FGF21 (show FGF21 Proteins) axis
NUPR1/RELB (show RELB Proteins)/IER3 (show IER3 Proteins)/RUNX2 (show RUNX2 Proteins) pathway has a pivotal role in hepatocarcinogenesis.
Hexavalent Cr(VI) induces Nupr1 and rapidly perturbs gene expression by downregulating H4K16 acetylation, thereby contributing to Cr(VI)-induced carcinogenesis.
findings suggest that local interactions and hydrophobic effects play a major role in determining the electrostatic features of NUPR1, whereas long-range charge contributions appear to be of lesser importance.
Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 (show DNMT1 Proteins) expression and consequently genome-wide levels of DNA methylation (show HELLS Proteins).
Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.
Mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1-granulin (show GRN Proteins) pathway, play pivotal roles in liver cancer progression
Functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.
Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity.
Nupr1 aids oncogenic Kras to bypass senescence in a manner that cooperatively promotes pancreas intraepithelial neoplasia formation.
data shows that p8 deficiency increases ROS (show ROS1 Proteins) and subsequently the expression of anti-oxidative enzymes, such as HO-1 (show HMOX1 Proteins), suggesting an involvement in the anti-oxidative defense.
According to Nupr1 status, KIC mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.
Nupr1 expression is required for IL-1beta (show IL1B Proteins)-mediated expression of MMP-13 (show MMP13 Proteins).
Inhibition of NUPR1 expression or activity has the potential to protect against the metabolic defects associated with obesity and type 2 diabetes.
a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic Kras(G12D)-dependent transformation of the pancreas.
progressive PPARalpha (show PPARA Proteins)- and p8-mediated ER stress contribute to the hepatocarcinogenesis in ACOX1 (show ACOX1 Proteins)(-/-) mice
Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype.
candidate of metastasis 1
, nuclear protein 1
, protein p8
, p8 protein
, nuclear protein, transcriptional regulator, 1
, Candidate of metastasis 1
, Nuclear transcriptional regulator protein 1
, Protein p8
, nuclear protein 1-like
, nuclear proten 1
, nuclear transcriptional regulator protein 1