anti-Nucleobindin 2 (NUCB2) Antibodies

NUCB2 encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. Additionally we are shipping Nucleobindin 2 Kits (43) and Nucleobindin 2 Proteins (28) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUCB2 4925 P80303
NUCB2 53322 P81117
NUCB2 59295 Q9JI85
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Top anti-Nucleobindin 2 Antibodies at

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-NUCB2 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate Human Intestine 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-NUCB2 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IAC, IEM, ICC, IP, IHC, WB 100 μL 9 to 11 Days
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Human HepG2 cell lysate; Primary Ab: 1µg/ml Rabbit Anti-Human NUCB2 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 13 to 16 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Stomach Tissue. 100 μg 13 to 16 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Mouse Rabbit Un-conjugated IHC (p), ELISA, WB Western blot analysis of Nucleobindin 2 expression in HEPA whole cell lysates (lane 1). Nucleobindin 2 at 55KD was detected using rabbit anti- Nucleobindin 2 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method Nucleobindin 2 was detected in paraffin-embedded sections of rat gaster tissues using rabbit anti- Nucleobindin 2 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Anti-NUCB2 / Nucleobindin 2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 0.05 mg 11 to 14 Days
Human Sheep Un-conjugated ELISA, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg 11 to 14 Days

Top referenced anti-Nucleobindin 2 Antibodies

  1. Human Polyclonal NUCB2 Primary Antibody for ELISA, WB - ABIN542488 : Oh-I, Shimizu, Satoh, Okada, Adachi, Inoue, Eguchi, Yamamoto, Imaki, Hashimoto, Tsuchiya, Monden, Horiguchi, Yamada, Mori: Identification of nesfatin-1 as a satiety molecule in the hypothalamus. in Nature 2006 (PubMed)
    Show all 4 Pubmed References

  2. Cow (Bovine) Polyclonal NUCB2 Primary Antibody for IHC, WB - ABIN2774832 : Linē, Stengrēvics, Slucka, Li, Jankevics, Rees: Serological identification and expression analysis of gastric cancer-associated genes. in British journal of cancer 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal NUCB2 Primary Antibody for ICC, IF - ABIN4338639 : Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012 (PubMed)

  4. Human Polyclonal NUCB2 Primary Antibody for IAC, IEM - ABIN2452060 : Taniguchi, Taniura, Niinobe, Takayama, Tominaga-Yoshino, Ogura, Yoshikawa: The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. in The Journal of biological chemistry 2000 (PubMed)

More Antibodies against Nucleobindin 2 Interaction Partners

Pig (Porcine) Nucleobindin 2 (NUCB2) interaction partners

  1. nesfatin-1 immunoreactive endocrine cells are present at the gastrointestinal level and sustains the necessity to study the role of this peptide in the regulation of food intake in farm species for which weight gain is essential for optimizing production

  2. It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig

  3. Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.

Human Nucleobindin 2 (NUCB2) interaction partners

  1. nesfatin-1 is potential novel biomarker for the prediction and early diagnosis of Gestational Diabetes Mellitus.

  2. Nesfatin-1 levels are inversely associated with severity of carotid artery stenosis and plaque morphology.

  3. Authors demonstrated that KLF4 was induced by ER stress in melanoma cells, and increased KLF4 inhibited cell apoptosis and promoted cell metastasis. Further mechanistic studies revealed that KLF4 directly bound to the promoter of NUCB2, facilitating its transcription.

  4. Nesfatin-1 is involved in cardiovascular regulation, stress-related responses.

  5. NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor

  6. Serum nesfatin-1 levels were significantly lower in major depressive disorder patients with suicidal ideation compared to healthy volunteers.

  7. Study data identified nesfatin-1 as a key modulator in hypertension and vascular remodeling by facilitating vascular smooth muscle cells phenotypic switching and proliferation.

  8. intensity of exercise may have an important role in changes of nesfatin-1, leptin, FFA, and epinephrine concentrations even though this was not the case for IL-6 and insulin resistance

  9. Patients with schizophrenia had significantly higher serum nesfatin-1 levels compared to healthy controls.

  10. This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match.

  11. serum nesfatin-1 concentrations were inversely correlated with atrial fibrillation development.

  12. In all trimesters of human pregnancy, NUCB2/nesfatin-1 was highly expressed in syncytiotrophoblast. In addition, there was a significant increase in NUCB2 expression in human primary trophoblast cells induced to syncytialise.

  13. Data suggest that circulating nesfatin-1 levels are up-regulated in patients newly diagnosed with type 2 diabetes; non-newly diagnosed patients treated with antidiabetic medications exhibit lower circulating nesfatin-1 levels. [META-ANALYSIS, REVIEW]

  14. Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity.

  15. expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism.

  16. Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma.

  17. The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.

  18. Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT) in colon cancer cells through LKB1/AMPK/TORC1/ZEB1 pathways in vitro and in vivo.

  19. Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health.

  20. women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed.

Cow (Bovine) Nucleobindin 2 (NUCB2) interaction partners

  1. Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.

Mouse (Murine) Nucleobindin 2 (NUCB2) interaction partners

  1. Findings suggested that the hypogonadotropic hypogonadism associated with obesity may be induced by reduced hypothalamic NUCB2/nesfatin-1 levels.

  2. NUCB2/nesfatin-1 is expressed in mouse placenta. Significant expression of NUCB2 in primary trophoblast cells during syncytialisation.

  3. The results demonstrate a novel role of PDK1 in AgRP neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 neurons.

  4. Nesfatin-1 promotes the differentiation of brown adipocytes likely through the mTOR dependent mechanism.

  5. Because Kv channel inhibition enhances insulin secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin secretion through regulation of ion channels rather than its unidentified receptor.

  6. Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.

  7. Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.

  8. The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP and oxytocin and consequently the fluid and energy balance.

  9. Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK-dependent mechanism.

  10. reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.

  11. new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK and PYY expression and secretion

  12. MGN3-1 cells respond differently to nutrients in secreting NUCB2/nesfatin-1 and ghrelin. Similarly, acute or chronic intake of nutrients does influence NUCB2 mRNA expression and NUCB2/nesfatin-1 release in a diet specific manner.

  13. Our data suggested that nesfatin-1 exerted its neuroprotective effect on dopaminergic cells against rotenone by ameliorating mitochondrial dysfunction and its anti-apoptotic property.

  14. NUCB2/nesfatin-1 is co-localized with GLP-1 and GIP in small intestinal cells. Data support the hypothesis that nesfatin-1 is present in enteroendocrine cells and that it stimulates incretin secretion.

  15. These results indicate that paraventricular nucleus NUCB2/nesfatin-1 is directly targeted by leptin, and mediates its anorexigenic effect.

  16. influence of nesfatin-1 on lipid metabolism either in physiological or diabetic conditions

  17. study demonstrated cytoplasmic localization of NUCB2/nesfatin-1 peptide in both human and murine chondrocytes.

  18. pro-osteogenic activity of NUCB2(1-83)

  19. These data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal.

  20. nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation

Nucleobindin 2 (NUCB2) Antigen Profile

Protein Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.

Gene names and symbols associated with anti-Nucleobindin 2 (NUCB2) Antibodies

  • nucleobindin 2 (nucb2) antibody
  • nucleobindin 2 (NUCB2) antibody
  • nucleobindin 2 (Nucb2) antibody
  • nucleobindin 2 L homeolog (nucb2.L) antibody
  • AI607786 antibody
  • Calnuc antibody
  • MGC97715 antibody
  • Nefa antibody
  • Nesfatin-1 antibody
  • NUCB2 antibody
  • nucleobindin-2 antibody
  • p54 antibody

Protein level used designations for anti-Nucleobindin 2 (NUCB2) Antibodies

nucleobindin 2 , nucleobindin-2-like , nucleobindin-2 , DNA-binding protein NEFA , gastric cancer antigen Zg4 , nesfatin-1 , nucleobinding 2 , prepronefastin , prepronesfatin

548541 Xenopus (Silurana) tropicalis
697084 Macaca mulatta
748720 Pan troglodytes
100028683 Monodelphis domestica
100056479 Equus caballus
100340960 Oryctolagus cuniculus
100456754 Pongo abelii
100481866 Ailuropoda melanoleuca
100512826 Sus scrofa
100562264 Anolis carolinensis
100600078 Nomascus leucogenys
423071 Gallus gallus
4925 Homo sapiens
476876 Canis lupus familiaris
509003 Bos taurus
53322 Mus musculus
59295 Rattus norvegicus
445873 Xenopus laevis
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