anti-Nucleobindin 2 (NUCB2) Antibodies

Pig (Porcine) Nucleobindin 2 (NUCB2) interaction partners

1. nesfatin-1 immunoreactive endocrine cells are present at the gastrointestinal level and sustains the necessity to study the role of this peptide in the regulation of food intake in farm species for which weight gain is essential for optimizing production

2. It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig

3. Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.

Human Nucleobindin 2 (NUCB2) interaction partners

1. NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor

2. Serum nesfatin-1 levels were significantly lower in major depressive disorder patients with suicidal ideation compared to healthy volunteers.

3. Study data identified nesfatin-1 as a key modulator in hypertension and vascular remodeling by facilitating vascular smooth muscle cells phenotypic switching and proliferation.

4. intensity of exercise may have an important role in changes of nesfatin-1, leptin, FFA, and epinephrine concentrations even though this was not the case for IL-6 and insulin resistance

5. Patients with schizophrenia had significantly higher serum nesfatin-1 levels compared to healthy controls.

6. This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match.

7. serum nesfatin-1 concentrations were inversely correlated with atrial fibrillation development.

8. In all trimesters of human pregnancy, NUCB2/nesfatin-1 was highly expressed in syncytiotrophoblast. In addition, there was a significant increase in NUCB2 expression in human primary trophoblast cells induced to syncytialise.

9. Data suggest that circulating nesfatin-1 levels are up-regulated in patients newly diagnosed with type 2 diabetes; non-newly diagnosed patients treated with antidiabetic medications exhibit lower circulating nesfatin-1 levels. [META-ANALYSIS, REVIEW]

10. Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity.

11. expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism.

12. Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma.

13. The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.

14. Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT) in colon cancer cells through LKB1/AMPK/TORC1/ZEB1 pathways in vitro and in vivo.

15. Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health.

16. women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed.

17. Our study was the first to investigate the nesfatin 1 levels in patients with the first episode psychosis. Based on our study results, nesfatin 1 might be related to some central nervous system pathologies, including the severity of a psychiatric disorder.

18. nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients.

19. Based on the obtained results, it was proposed that ghrelin may be considered as playing a role in the etiopathogenesis of hyperemesis gravidarum that may result in disruption of the relationship between nesfatin-1 and ghrelin.

20. This study supports the role of insulin resistance in decreased nesfatin-1 levels in patients with Type 2 diabetes mellitus and metabolic syndrome

Cow (Bovine) Nucleobindin 2 (NUCB2) interaction partners

1. Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.

Mouse (Murine) Nucleobindin 2 (NUCB2) interaction partners

1. NUCB2/nesfatin-1 is expressed in mouse placenta. Significant expression of NUCB2 in primary trophoblast cells during syncytialisation.

2. The results demonstrate a novel role of PDK1 in AgRP neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 neurons.

3. Nesfatin-1 promotes the differentiation of brown adipocytes likely through the mTOR dependent mechanism.

4. Because Kv channel inhibition enhances insulin secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin secretion through regulation of ion channels rather than its unidentified receptor.

5. Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.

6. Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.

7. The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP and oxytocin and consequently the fluid and energy balance.

8. Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK-dependent mechanism.

9. reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.

10. new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK and PYY expression and secretion

11. MGN3-1 cells respond differently to nutrients in secreting NUCB2/nesfatin-1 and ghrelin. Similarly, acute or chronic intake of nutrients does influence NUCB2 mRNA expression and NUCB2/nesfatin-1 release in a diet specific manner.

12. Our data suggested that nesfatin-1 exerted its neuroprotective effect on dopaminergic cells against rotenone by ameliorating mitochondrial dysfunction and its anti-apoptotic property.

13. NUCB2/nesfatin-1 is co-localized with GLP-1 and GIP in small intestinal cells. Data support the hypothesis that nesfatin-1 is present in enteroendocrine cells and that it stimulates incretin secretion.

14. These results indicate that paraventricular nucleus NUCB2/nesfatin-1 is directly targeted by leptin, and mediates its anorexigenic effect.

15. influence of nesfatin-1 on lipid metabolism either in physiological or diabetic conditions

16. study demonstrated cytoplasmic localization of NUCB2/nesfatin-1 peptide in both human and murine chondrocytes.

17. pro-osteogenic activity of NUCB2(1-83)

18. These data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal.

19. nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation

20. Gastric mTOR is a gastric energy sensor whose activity is linked to the regulation of gastric nesfatin-1/NUCB2.