Nucleobindin 2 Proteins (NUCB2)

NUCB2 encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. Additionally we are shipping Nucleobindin 2 Antibodies (84) and Nucleobindin 2 Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NUCB2 4925 P80303
NUCB2 53322 P81117
NUCB2 59295 Q9JI85
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Top Nucleobindin 2 Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 20 μg Log in to see 8 to 11 Days
$218.90
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 15 to 16 Days
$325.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 12 Days
$343.47
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,094.67
Details
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 4 Days
$234.03
Details

NUCB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,

More Proteins for Nucleobindin 2 (NUCB2) Interaction Partners

Pig (Porcine) Nucleobindin 2 (NUCB2) interaction partners

  1. It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig

  2. Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.

Human Nucleobindin 2 (NUCB2) interaction partners

  1. serum nesfatin-1 concentrations were inversely correlated with atrial fibrillation development.

  2. In all trimesters of human pregnancy, NUCB2/nesfatin-1 was highly expressed in syncytiotrophoblast. In addition, there was a significant increase in NUCB2 expression in human primary trophoblast cells induced to syncytialise.

  3. Data suggest that circulating nesfatin-1 levels are up-regulated in patients newly diagnosed with type 2 diabetes; non-newly diagnosed patients treated with antidiabetic medications exhibit lower circulating nesfatin-1 levels. [META-ANALYSIS, REVIEW]

  4. Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity.

  5. expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism.

  6. Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma (show MOK Proteins).

  7. The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.

  8. Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT (show ITK Proteins)) in colon cancer cells through LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins)/TORC1 (show CRTC1 Proteins)/ZEB1 pathways in vitro and in vivo.

  9. Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health.

  10. women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed.

Cow (Bovine) Nucleobindin 2 (NUCB2) interaction partners

  1. Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.

Mouse (Murine) Nucleobindin 2 (NUCB2) interaction partners

  1. NUCB2/nesfatin-1 is expressed in mouse placenta. Significant expression of NUCB2 in primary trophoblast cells during syncytialisation.

  2. The results demonstrate a novel role of PDK1 (show PDPK1 Proteins) in AgRP (show AGRP Proteins) neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 neurons.

  3. Nesfatin-1 promotes the differentiation of brown adipocytes likely through the mTOR (show FRAP1 Proteins) dependent mechanism.

  4. Because Kv channel inhibition enhances insulin (show INS Proteins) secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin (show INS Proteins) secretion through regulation of ion channels rather than its unidentified receptor.

  5. Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.

  6. Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.

  7. The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP (show AVP Proteins) and oxytocin and consequently the fluid and energy balance.

  8. Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK (show PRKAA1 Proteins)-dependent mechanism.

  9. reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.

  10. new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK (show CCK Proteins) and PYY expression and secretion

Nucleobindin 2 (NUCB2) Protein Profile

Protein Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.

Gene names and symbols associated with Nucleobindin 2 Proteins (NUCB2)

  • nucleobindin 2 (nucb2)
  • nucleobindin 2 (NUCB2)
  • nucleobindin 2 (Nucb2)
  • nucleobindin 2 L homeolog (nucb2.L)
  • AI607786 protein
  • Calnuc protein
  • MGC97715 protein
  • Nefa protein
  • Nesfatin-1 protein
  • NUCB2 protein
  • nucleobindin-2 protein
  • p54 protein

Protein level used designations for Nucleobindin 2 Proteins (NUCB2)

nucleobindin 2 , nucleobindin-2-like , nucleobindin-2 , DNA-binding protein NEFA , gastric cancer antigen Zg4 , nesfatin-1 , nucleobinding 2 , prepronefastin , prepronesfatin

GENE ID SPECIES
548541 Xenopus (Silurana) tropicalis
697084 Macaca mulatta
748720 Pan troglodytes
100028683 Monodelphis domestica
100056479 Equus caballus
100340960 Oryctolagus cuniculus
100456754 Pongo abelii
100481866 Ailuropoda melanoleuca
100512826 Sus scrofa
100562264 Anolis carolinensis
100600078 Nomascus leucogenys
423071 Gallus gallus
4925 Homo sapiens
476876 Canis lupus familiaris
509003 Bos taurus
53322 Mus musculus
59295 Rattus norvegicus
445873 Xenopus laevis
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