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NUCB2 encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells.
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It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig
Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.
Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity.
expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism.
Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma (show MOK Proteins).
The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.
Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT (show ITK Proteins)) in colon cancer cells through LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins)/TORC1 (show CRTC1 Proteins)/ZEB1 pathways in vitro and in vivo.
Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health.
women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed.
Our study was the first to investigate the nesfatin 1 levels in patients with the first episode psychosis. Based on our study results, nesfatin 1 might be related to some central nervous system pathologies, including the severity of a psychiatric disorder.
nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients.
Based on the obtained results, it was proposed that ghrelin (show GHRL Proteins) may be considered as playing a role in the etiopathogenesis of hyperemesis gravidarum that may result in disruption of the relationship between nesfatin-1 and ghrelin (show GHRL Proteins).
Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.
Nesfatin-1 promotes the differentiation of brown adipocytes likely through the mTOR (show FRAP1 Proteins) dependent mechanism.
Because Kv channel inhibition enhances insulin (show INS Proteins) secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin (show INS Proteins) secretion through regulation of ion channels rather than its unidentified receptor.
Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.
Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.
The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP (show AVP Proteins) and oxytocin and consequently the fluid and energy balance.
Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK (show PRKAA1 Proteins)-dependent mechanism.
reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.
new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK (show CCK Proteins) and PYY expression and secretion
MGN3-1 cells respond differently to nutrients in secreting NUCB2/nesfatin-1 and ghrelin (show GHRL Proteins). Similarly, acute or chronic intake of nutrients does influence NUCB2 mRNA expression and NUCB2/nesfatin-1 release in a diet specific manner.
Our data suggested that nesfatin-1 exerted its neuroprotective effect on dopaminergic cells against rotenone by ameliorating mitochondrial dysfunction and its anti-apoptotic property.
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.
, DNA-binding protein NEFA
, gastric cancer antigen Zg4
, nucleobinding 2