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NUCB2 encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. Additionally we are shipping Nucleobindin 2 Antibodies (163) and Nucleobindin 2 Kits (76) and many more products for this protein.
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It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig
Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.
The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.
Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT (show ITK Proteins)) in colon cancer cells through LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins)/TORC1 (show CRTC1 Proteins)/ZEB1 pathways in vitro and in vivo.
Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health.
women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed.
Our study was the first to investigate the nesfatin 1 levels in patients with the first episode psychosis. Based on our study results, nesfatin 1 might be related to some central nervous system pathologies, including the severity of a psychiatric disorder.
nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients.
Based on the obtained results, it was proposed that ghrelin (show GHRL Proteins) may be considered as playing a role in the etiopathogenesis of hyperemesis gravidarum that may result in disruption of the relationship between nesfatin-1 and ghrelin (show GHRL Proteins).
This study supports the role of insulin (show INS Proteins) resistance in decreased nesfatin-1 levels in patients with Type 2 diabetes mellitus and metabolic syndrome
Increased plasma nesfatin-1 concentrations are associated closely with inflammation, trauma severity and clinical outcomes, indicating that nesfatin-1 might be involved in inflammation and become a good prognostic biomarker following traumatic brain injury
Data suggest that NUCB2 (almost negligible in normal endometrium) plays pivotal roles in cell proliferation and migration/invasiveness of endometrial carcinoma; NUCB2 may serve as a prognostic biomarker for endometrial carcinoma. Expression of NUCB2 appears almost negligible in normal endometrium.
Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.
Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.
Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.
The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP (show AVP Proteins) and oxytocin and consequently the fluid and energy balance.
Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK (show PRKAA1 Proteins)-dependent mechanism.
reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.
new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK (show CCK Proteins) and PYY expression and secretion
MGN3-1 cells respond differently to nutrients in secreting NUCB2/nesfatin-1 and ghrelin (show GHRL Proteins). Similarly, acute or chronic intake of nutrients does influence NUCB2 mRNA expression and NUCB2/nesfatin-1 release in a diet specific manner.
Our data suggested that nesfatin-1 exerted its neuroprotective effect on dopaminergic cells against rotenone by ameliorating mitochondrial dysfunction and its anti-apoptotic property.
NUCB2/nesfatin-1 is co-localized with GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) in small intestinal cells. Data support the hypothesis that nesfatin-1 is present in enteroendocrine cells and that it stimulates incretin secretion.
These results indicate that paraventricular nucleus NUCB2/nesfatin-1 is directly targeted by leptin (show LEP Proteins), and mediates its anorexigenic effect.
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.
, DNA-binding protein NEFA
, gastric cancer antigen Zg4
, nucleobinding 2