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May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). Additionally we are shipping NXNL1 Antibodies (48) and and many more products for this protein.
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Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones.
Data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract.
regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
CHX10 regulates RdCVF promoter activity in the inner retina.
is a truncated thioredoxin-like protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa
RdCVF variants have roles in leber congenital amaurosis
TXNL6 probably protects retinal cells from photooxidative damage-induced apoptosis via upregulation of NF-kappaB activity
RdCVFL is a cell-autonomous mechanism of protection.
The Nxnl1 gene, through the thioredoxin RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress.
The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.
functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity).
nucleoredoxin-like protein 1
, rod-derived cone viability factor
, thioredoxin-like 6
, thioredoxin-like protein 6