Nucleoredoxin Like Protein 1 Proteins (NXNL1)

Human Nucleoredoxin Like Protein 1 (NXNL1) interaction partners

1. Study shows that RdCVF acts through binding to Basigin-1 (BSG1 (show ZBTB24 Proteins)), a transmembrane protein expressed specifically by photoreceptors. BSG1 (show ZBTB24 Proteins) binds to the glucose transporter GLUT1 (show SLC2A1 Proteins), resulting in increased glucose entry into cones.

2. Data suggest a critical role for TXNL6 in MsrA (show MSRA Proteins) repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA (show MSRA Proteins) defense protection against cataract.

3. regulation of the Nucleoredoxin (show NXN Proteins)-like genes involves a CRX (show CRX Proteins) responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity

4. CHX10 (show VSX2 Proteins) regulates RdCVF promoter activity in the inner retina.

5. is a truncated thioredoxin-like (show TXN Proteins) protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa

6. RdCVF variants have roles in leber congenital amaurosis

7. TXNL6 probably protects retinal cells from photooxidative damage-induced apoptosis via upregulation of NF-kappaB (show NFKB1 Proteins) activity

Mouse (Murine) Nucleoredoxin Like Protein 1 (NXNL1) interaction partners

1. Study shows that RdCVF acts through binding to Basigin-1 (BSG1 (show ZBTB24 Proteins)), a transmembrane protein expressed specifically by photoreceptors. BSG1 (show ZBTB24 Proteins) binds to the glucose transporter GLUT1 (show SLC2A1 Proteins), resulting in increased glucose entry into cones.

2. The Nxnl1 gene, through the thioredoxin (show TXN Proteins) RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress.

3. regulation of the Nucleoredoxin (show NXN Proteins)-like genes involves a CRX (show CRX Proteins) responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity

4. The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.

5. CHX10 (show VSX2 Proteins) regulates RdCVF promoter activity in the inner retina.