Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) ELISA Kits

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Antibodies (67) and NUDT1 Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
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Top NUDT1 ELISA Kits at antibodies-online.com

Showing 3 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.23 ng/mL 0.78-50 ng/mL   96 Tests 2 to 3 Days
$779.90
Details
Mouse
  96 Tests 11 to 18 Days
$618.29
Details
Rat
  96 Tests 11 to 18 Days
$618.29
Details

More ELISA Kits for NUDT1 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. Our results suggest that the contribution of NUDT1 and OGG1 germline mutations to hereditary colorectal cancer (CRC) and to polyposis is inexistent or, at most, negligible. The inclusion of these genes in routine genetic testing is not recommended.

  2. MTH1 is important for removal of methylated nucleotides from the nucleotide pool

  3. overall our cell viability data indicates that targeting MTH1 will likely not be an across-the-board effective non-small cell lung cancer therapeutic strategy; rather it induces non-cytotoxic DNA damage that could promote cancer heterogeneity and evolution.

  4. MTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.

  5. PRDX1 and MTH1 cooperate to prevent accumulation of oxidized guanine in the genome

  6. Results provide evidence that MTH1 is not essential for cancer cell survival.

  7. CDT1, MCM7, and NUDT1 were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone.

  8. Our results reveal a novel antitumor mechanism of (S)-crizotinib in NSCLC which involves activation of ROS-dependent ER stress apoptotic pathway and is independent of MTH1 inhibition

  9. this study showed that MTH1 protein expression was closely related to factors associated with a high malignant potential and poor patient survival

  10. method for predicting individual residue contributions to enzyme specificity and binding-site energies, and its application to MTH1.

  11. Data indicate the specificity of the enzyme 8-oxo-dGTPase MTH1 toward the substrate 8-oxo-dGTP.

  12. We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.

  13. Data indicate a positive correlation of Skp2 and MTH1 expression in melanoma cell lines and patient specimens.

  14. Results show that MTH1 is overexpressed in esophageal squamous cell carcinoma, and suggestive of disease progression.

  15. MTH1 together with MYH plays an important role in protection against mutations induced by modified dNTPs during chronic oxidative stress.

  16. Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutations occur in diffuse-type adenocarcinoma of gastric cardia.

  17. Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp-119 and Asp-120) in its substrate binding pocket

  18. MTH1 inhibition may offer a general approach to treat cancers characterized by deregulated hypoxia signaling or redox imbalance

  19. MTH-1 expression in colorectal cancer cells was upregulated via HIF-1alpha in response to hypoxic stress, emphasizing the crucial role of HIF-1alpha-induced MTH-1 in tumor growth.

  20. activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. Increased cytotoxicity following MTH1 knockout or treatment with MTH1 inhibitor suggests the oxidation of precursor nucleotides.

  2. The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented.

  3. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  4. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  5. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

  6. An age-related higher level of 8-oxodG even occurs concomitantly with high 8-oxodGTPase activity.

NUDT1 Antigen Profile

Antigen Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) antibody
  • nudix hydrolase 1 (nudt1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp) antibody
  • nudix hydrolase 1 (NUDT1) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) antibody
  • nudix hydrolase 1 (Nudt1) antibody
  • Mth1 antibody
  • mutT antibody
  • nudT1 antibody

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
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