anti-OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) Antibodies

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Additionally we are shipping OMA1 Kits (5) and OMA1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OMA1 115209 Q96E52
OMA1 298282 D3ZS74
OMA1 67013 Q9D8H7
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Top anti-OMA1 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-OMA1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate Sample Type: HepG2 cellsPrimary Dilution: 1:1000Secondary Antibody: anti-Rabbit TBST with 5% BSASecondary Dilution: 1:5000Image Submitted by: Hana SabicUniversity of Utah 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of K-562 cells, using OMA1 antibody. ABIN6273279 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB OMA1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated WB Rat heart lysates probed with OMA1 Polyclonal Antibody, Unconjugated at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Biotin WB   100 μL 14 to 21 Days
$394.90
Details
Human Rabbit HRP WB   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using OMA1 antibody (ABIN6294095) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 50 μL 11 to 13 Days
$308.12
Details
Human Rabbit Biotin ELISA   100 μg 11 to 16 Days
$469.05
Details
Human Rabbit FITC ELISA   100 μg 11 to 16 Days
$469.05
Details

Top referenced anti-OMA1 Antibodies

  1. Cow (Bovine) Polyclonal OMA1 Primary Antibody for WB - ABIN2785108 : Bohovych, Donaldson, Christianson, Zahayko, Khalimonchuk: Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast. in The Journal of biological chemistry 2014 (PubMed)
    Show all 2 Pubmed References

More Antibodies against OMA1 Interaction Partners

Human OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) interaction partners

  1. Mitochondrial membrane potential loss-dependent PINK1 import arrest does not result solely from Tim23 inactivation but also through an actively regulated "tug of war" between Tom7 and OMA1.

  2. differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.

  3. The mitochondrial metalloprotease OMA1 was activated in a Bax- and Bak-dependent fashion.

  4. Cleavage of the inner membrane fusion factor L-OPA1 is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential.

  5. OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin knockdown in cells.

  6. These findings demonstrate that (a) p53 and Oma1 mediate L-Opa1 processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics

  7. OMA1 controls OPA1 cleavage and function.

  8. These results provide evidence for different substrate specificities of m-AAA proteases composed of different subunits and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin-like GTPases in mitochondria.

Mouse (Murine) OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) interaction partners

  1. The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria.

  2. stress-induced OMA1 activation and guanosine triphosphatase OPA1 cleavage limit mitochondrial fusion and promote neuronal death

  3. The IMQC protease Oma1 is required for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.

  4. OMA1-mediated OPA1 proteolysis plays an important role in the disruption of mitochondrial dynamics in ischemic acute kidney injury.

  5. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.

  6. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

  7. This study shows that OMA1 plays an essential role in the proteolytic inactivation of the dynamin-related GTPase OPA1 and describes its unexpected role in energy metabolism

  8. OMA1 regulates OPA1 cleavage in the mitochondrial inner membrane.

OMA1 Antigen Profile

Protein Summary

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity).

Gene names and symbols associated with OMA1

  • OMA1 zinc metallopeptidase (OMA1) antibody
  • OMA1 zinc metallopeptidase (Oma1) antibody
  • si:ch73-215a11.1 (si:ch73-215a11.1) antibody
  • 2010001O09Rik antibody
  • DAB1 antibody
  • MPRP-1 antibody
  • oma1 antibody
  • peptidase antibody
  • RGD1304821 antibody
  • YKR087C antibody
  • ZMPOMA1 antibody

Protein level used designations for OMA1

OMA1 homolog, zinc metallopeptidase , OMA1 zinc metallopeptidase homolog , metalloendopeptidase OMA1, mitochondrial , metalloprotease related protein 1 , metalloprotease-related protein 1 , overlapping activity with M-AAA protease , overlapping with the m-AAA protease 1 homolog , zinc metallopeptidase OMA1 , Metalloendopeptidase OMA1, mitochondrial , OMA1 zinc metallopeptidase , Overlapping with the m-AAA protease 1 homolog , Metalloendopeptidase OMA1, mitochondrial-like protein , metalloendopeptidase OMA1 mitochondrial-like protein

GENE ID SPECIES
115209 Homo sapiens
298282 Rattus norvegicus
67013 Mus musculus
506223 Bos taurus
100730704 Cavia porcellus
100331186 Danio rerio
100338330 Oryctolagus cuniculus
489569 Canis lupus familiaris
100067642 Equus caballus
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