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Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1 (By similarity). Additionally we are shipping ORAI2 Proteins (3) and and many more products for this protein.
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Human Polyclonal ORAI2 Primary Antibody for IF, WB - ABIN541303
Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001
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Human Polyclonal ORAI2 Primary Antibody for ICC, ELISA - ABIN1002946
Soboloff, Spassova, Dziadek, Gill: Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. in Biochimica et biophysica acta 2006
Show all 3 Pubmed References
ORAI1-3, are preferentially expressed in proximal tubular epithelial cells and downregulated in patients with diabetic nephropathy.
findings provide evidence for a role for Orai1 and Orai2, in SOCE and migration in the human HL60 promyeloblastic cell line
results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Orai1, Orai2 and STIM1 form functional Ca(2+) release-activated Ca(2+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2+) entry in response to agonist stimulation.
The higher amplitude of store-operated Ca2+ entry was associated to the over-expression for Stim2, Orai2-3, and TRPC1 while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in primary myelofibrosis.
Orai1 but not Orai2 plays a major role in the influx of extracellular Ca2+ into and mediator release from HLMCs following their activation
Orai1 and Orai2 operate in a STIM-dependent manner, Orai3 does not interact with STIM isoforms upon calcium store depletion in platelets.
With these data we show a new Ca(2)(+) entry pathway linked to the Ca(2)(+)/inositolphosphate second-messenger system in RPE cells which help to further understand regulatory pathways of agonists.
Results suggest that Orai1, -2, and -3 channels are similarly inhibited by extracellular calcium, indicating similar affinities for Ca(2+) within the selectivity filter.
The effects of 2-aminoethoxydiphenyl borate on orai1, orai2, orai3 metabolism in HEK293 cells with and without STIM1 are reported.
analysis of activation of Orai1-3 channels by a STIM1 coiled-coil mutant
Data show that the fast Ca(2+)-dependent inactivation is mediated by three conserved glutamates in the C termini (CT) of Orai2 and Orai3, which show prominent fast Ca(2+)-dependent inactivation compared with Orai1.
Orai2 proteins contribute to Ca(2+) entry in connective tissue type mast cells in discrete operation modes depending on the availability of calcium ions in the extracellular space.
ORAI1 and ORAI2 form heteromeric Ca(2+) release-activated Ca(2+) channels, in which ORAI2 fine-tunes the magnitude of Store-operated Ca(2+) entry to modulate immune responses.
This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.
The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.
Data indicate that the Ca(2+) release-activated Ca(2+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+) entry in a concentration-dependent manner.
Orai2 is specifically up-regulated during the G2/M phase, negatively modulates the store-operated Ca(2+) entry activity, and may contribute to the regulation of cell cycle progression in brain capillary endothelial cells.
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1 (By similarity).
CAP-binding protein complex interacting protein 2
, CAP-binding protein complex-interacting protein 2
, protein orai-2
, putative protein ORAI2-2
, transmembrane protein 142B
, calcium release-activated calcium channel 2
, calcium release-activated calcium modulator 2 protein
, ORAI calcium release-activated calcium modulator 2
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A