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The protein encoded by OPRL1 is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin.
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The rs2229205 SNP in the OPRL1 gene may be a genetic factor that contributes to individual differences in the vulnerability to smoking in Japanese individuals
The results of in vitro Ala scanning analyses revealed that the labeled residues were Cys59 in TM1 (show TPM2 ELISA Kits), Cys215 and Cys231 in TM5, and Cys310 in TM7. The present study has provided a novel method of Cys (show DNAJC5 ELISA Kits)(Npys)-affinity labeling for identification of the ligand-binding sites in the ORL1 receptor.
Study presents evidence suggesting that the PNOC (show PNOC ELISA Kits) and OPRL1 are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis
Data suggest that nociceptin (show PNOC ELISA Kits) and nociceptin receptor evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW]
Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin (show PNOC ELISA Kits) and nociceptin receptor system in arcuate nucleus of hypothalamus is such a system. [REVIEW]
Data suggest that the nociceptin/nociceptin (show PNOC ELISA Kits) receptor system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]
Data suggest that the nociceptin/nociceptin (show PNOC ELISA Kits) receptor system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]
Data suggest that interaction between the nociceptin/nociceptin (show PNOC ELISA Kits) receptor system and the orexin/orexin (show OX ELISA Kits) receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Data suggest that nociceptin/nociceptin (show PNOC ELISA Kits) receptor signaling in neurons of the hippocampus modulate learning and memory. [REVIEW]
Overall methylation levels in the promoter regions of three genes (ALDH1A1 (show ALDH1A1 ELISA Kits), OPRL1 and RGS19 (show RGS19 ELISA Kits)) are elevated in subjects who were exposed to childhood adversity.
nociceptin (show PNOC ELISA Kits) opioid receptor agonists are promising drugs for treating pain in sickle cell anemia.
These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons.
Oprl1 is associated with amygdala function, fear processing, and posttraumatic stress disorder symptoms.
the present results suggest that the endogenous OFQ/N/NOP receptor system may modulate the development of cocaine-induced locomotor sensitization.
Data suggest that NOPR and MOPR (mu-type opioid receptor (show OPRM1 ELISA Kits)) in spinal cord independently drive antinociception; NOPR/MOPR (show OPRM1 ELISA Kits) ligands attenuate neuropathic/inflammatory pain and have high antinociceptive potency with low tolerance development.
Data suggest that nociceptin receptor/nociceptin (show PNOC ELISA Kits) signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
The results of this study demonstrated the contribution of the NOP receptor in controlling food intake and meal pattern, as well as glutamate (show GRIN1 ELISA Kits) release and GIRK1 (show KCNJ3 ELISA Kits) channel activity at POMC (show POMC ELISA Kits) synapses.
N/OFQ and NOP receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions
These results suggest differential requirements for ORL(1) in the mediation of neuroimmune effects exerted at different times after an immune challenge.
OPR is not crucial for development of either acute or neuropathic nociceptive responses, or for the regulation of full receptor-mediated responses to opioid agonists
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene.
opiate receptor-like 1
, opioid receptor XOR1
, kappa-type 3 opioid receptor
, kappa3-related opioid receptor
, nociceptin receptor
, orphanin FQ receptor
, nociceptin receptor ORL1
, opioid receptor-like 1
, orphanin FQ receptor-a
, orphanin FQ receptor-b
, orphanin FQ receptor-e
, peptide receptor
, seven transmembrane G protein-coupled receptor
, K3 opiate receptor
, orphanin FQ/nociceptin receptor
, N/OFQ receptor
, nociceptin/ orphaninFQ receptor
, opioid-receptor-like protein