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OVGP1 encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. Additionally we are shipping OVGP1 Kits (15) and OVGP1 Proteins (6) and many more products for this protein.
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Human Polyclonal OVGP1 Primary Antibody for WB - ABIN541380
Arias, Verhage, Jaffe: Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. in Biology of reproduction 1995
Show all 2 Pubmed References
OVGP1 is specifically induced in the luminal epithelium at the time of embryo implantation where it regulates receptivity-related genes and aids in trophoblast adhesion.
Decreased gene expression of MUC9 was found from colonic biopsies in patients with active and remission ulcerative colitis.
OVGP1 seems to detect a different spectrum of ovarian epithelial cancers than other markers and thus should be a useful adjunct for more accurate detection, particularly of early serous ovarian cancers and mucinous carcinomas.
cloning and characterization of the promoter and gene expression regulation in the oviduct (human oviduct-specific glycoprotein, HuOPG)
The production and function of oviductin at different stages of human reproductive cycle is not well known. Its highest expression at the time of ovulation is consistent with a supportive role in fertilization and early embryo development.
Gain of oviduct-specific glycoprotein is associated with the development of endometrial hyperplasia and endometrial cancer
The presence of oviductin mRNA and protein has been determined in OE-E6/E7, an immortalized human oviductal epithelial cell line.
Results suggests the binding of OGP to human sperm mediates through MYH9.
Reflux laryngitis is associated with down-regulation of mucin gene expression.
In the ovary, Ovgp1 transcripts and protein were detected in the surface epithelium, granulosa cells of the preantral and the antral follicles and corpus luteum. In both, the ovary and oviduct, the expression of Ovgp1 was found to be higher at estrus stage than at diestrus stage. To the best of our knowledge, this is the first study demonstrating the extra-oviductal expression of Ovgp1
A line of OGP gene-null (ogp-/-) mice has been established and their reproductive properties have been primarily characterized; results indicate that OGP is not essential for the process of in vivo fertilization, at least in mice.
Results suggest that the mRNA level of mouse cervix oviductin was related to estrous cycle,implied with estrogen-dependence.
Data suggest that OVGP1 expression in oviductal epithelial cells is enhanced by PGE2 via PTGER2-cAMP-PKA signaling, and reduced by PGF2alpha through PTGFR-Ca2+-PKC pathway. (OVGP1 = oviductal glycoprotein 1; PTGER2 = prostaglandin E2 receptor; PTGFR = prostaglandin F2-alpha receptor; PKA = cyclic AMP-dependent protein kinase; PKC = protein kinase C)
the presence or absence of conserved regions in the C-terminus of OVGP1 modify its association with the zona pellucida that affects matrix structure and renders the zona matrix permissive to sperm penetration and OVGP1 endocytosis into the egg.
Assigned to porcine chromosome 4.
OVGP1 expression in the oviduct is 5,500 higher than in the uterus or ovary, whereas a low level of basal expression is detected in non-reproductive tissues.
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.
estrogen-dependent oviduct protein
, mucin 9
, oviduct glycoprotein
, oviduct-specific glycoprotein
, chitinase 5
, oviduct glycoprotein OGP
, oviductal glycoprotein 1, 120kD
, oviduct specific glycoprotein
, oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)
, oviductal secretory glycoprotein
, estrus-associated oviductal glycoprotein
, oviductal glycoprotein 1, 120kDa
, development promoting factor
, estradiol-dependent oviduct-specific glycoprotein