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Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Additionally we are shipping PAP Associated Domain Containing 4 Antibodies (34) and PAP Associated Domain Containing 4 Proteins (5) and many more products for this protein.
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our results propose a novel feedback regulatory mechanism for controlling HCV RNA abundance by the viral capsid protein, which is capable of modulating miR-122 activity and stability through the inhibition of GLD-2.
QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
HBx is a critical protein derived from HBV, which regulates miR-122 via down-regulating Gld2
The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly through catalyzing 3' monoadenylation
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
human CPE-binding protein 1 and hGLD-2 are antagonizing factors regulating p53 mRNA stability.
The authors show that the human CPEB1 can repress the activity of the reporter construct containing the HPV-16 early sequences. This repression can be counteracted by a human cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1.
In Gld2 knockout mice there are detectable alterations in specific miRNA monoadenylation in the hippocampus, but no detectable effect on miRNA stability and no overt change in animal behavior.
We found an association of mGLD-2 with cytoplasmic polyadenylation components, CPEB and CPSF described in Xenopus oocytes
mGLD-2 may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation.
identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3'-terminal adenylation of miR-122 after unwinding of the miR-122/miR-122* duplex
investigate whether the functions of the cytoplasmic poly(A) polymerase (cytoPAP) GLD-2 in C. elegans germ cells exclusively depend on its catalytic activity; findings highlight the enzymatic importance of noncanonical poly(A) polymerases and emphasize the pivotal role of poly(A) tail-centered cytoplasmic mRNA regulation in germ cell biology.
GLD-2 thus appears to have evolved specialized nucleotidyl-transferase properties that match the 3' end features of dormant cytoplasmic mRNAs
The analyses suggest that GLD-2 activity mediates mRNA stability of many translationally repressed mRNAs.
Data suggest that the FBF-2/GLD-2 protein directed polyadenylation of the endogenous mRNA, compensating for that mRNA's natural deadenylation.
Data suggest that the GLD-2/RNP-8 enzyme is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes.
Regulates Gld-1 messenger RNA in germ cells, enabling the transition from mitosis to meiosis.
FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction in control of GLD1 expression.
GLD-4 is predominantly expressed in germ cells, and its activity is essential for early meiotic progression of male and female gametes in the absence of GLD-2
In C. elegans hermaphrodites, gamete production begins with spermatogenesis and transitions later to oogenesis; the combinatorial use of GLD-2 contributes to this transition, as GLD-2/GLD-3 promotes spermatogenesis, and GLD-2/RNP-8 specifies oogenesis.
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germ line.
PAP-associated domain-containing protein 4
, TUTase 2
, poly(A) RNA polymerase GLD2
, terminal uridylyltransferase 2
, cytoplasmic poly(A) polymerase