PARG Proteins (PARG)

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Additionally we are shipping PARG Antibodies (50) and PARG Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARG 8505 Q86W56
PARG 26430  
Rat PARG PARG 83507 Q9QYM2
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Top PARG Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Insect cells (Sf21) Human His tag   2 μg Log in to see 5 to 8 Days
$381.38
Details

PARG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for PARG Interaction Partners

Human PARG interaction partners

  1. PARG is acetylated at multiple sites.PARG interacts with PCNA via a non-canonical PIP-box.

  2. PARG inhibition leads to stalled replication forks and increased homologous recombination (HRR). The lack of HRR proteins at PARG inhibitor-induced replication stalling that induces cell death.

  3. Data show that poly-(ADP-ribose) polymerase 1 (PARP1) opposes the function of poly-(ADP-ribose) glycohydrolase (PARG) during regulation of bone morphogenetic protein target gene expression.

  4. Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.

  5. Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.

  6. Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFB signaling.

  7. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.

  8. The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1/PARG gene expression balance.

  9. PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.

  10. poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.

  11. Therefore, strategies that target PAR metabolism for the improved treatment of cancer may be required to target PARP-1 and PARG individually in order to optimize cancer cell death.

  12. PARG silencing could inhibit the ability of HUVEC migration and proliferation by downregulating the activity of NF-kappaB in LoVo cells that in turn decreases angiogenic factors such as VEGF, b-FGF, ICAM-1, MMP-9, as well as phosphorylation of p38 and ERK.

  13. Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

  14. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression.

  15. inhibition of PARG leads to an accumulation of PAR polymers, the collapse of replication forks and the induction of homologous recombination in wild-type cells.

  16. PARG knockdown, concomitant with inhibition of PARP, suppressed the metastatic potency of colon carcinoma cells by activation of PI3K/Akt signaling pathway.

  17. The identification of a PARG isoform as a component of the mitochondrial matrix raises several interesting possibilities concerning mechanisms of nuclear-mitochondrial cross talk involved in regulation of cell death pathways.

  18. Subcellular localization of human poly(ADP-ribose) glycohydrolase in mammalian cells.

  19. PARG is expressed in alternatiuve splice variants yielding isoforms that localize to different cell compartments.

  20. PARG in modulating chromatin structure, participares in transcription, DNA repair and apoptosis [review].

PARG Protein Profile

Protein Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Gene names and symbols associated with PARG Proteins (PARG)

  • poly(ADP-ribose) glycohydrolase (PARG)
  • poly (ADP-ribose) glycohydrolase (Parg)
  • AI413217 protein
  • PARG99 protein

Protein level used designations for PARG Proteins (PARG)

mitochondrial poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase 60 kDa isoform , cytosolic poly(ADP-ribose) glycohydrolase , mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform

GENE ID SPECIES
8505 Homo sapiens
26430 Mus musculus
83507 Rattus norvegicus
281377 Bos taurus
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