anti-PARK2 Co-Regulated (PACRG) Antibodies

Human PARK2 Co-Regulated (PACRG) interaction partners

1. Mapping of the PARK2 and PACRG gene regulatory region with 96 SNPs, with a resolution of 1 SNP per 1 Kb for PARK2 gene regulatory region in a North Indian population, showed an involvement of 11 SNPs in determining the susceptibility towards leprosy.

2. PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome.

3. conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families

4. Elevated levels of PACRG result in increased neuronal autophagy.

5. single nucleotide polymorphisms of PARK2 with leprosy susceptibility in Chinese population

6. the association of polymorphisms rs9356058 and rs1040079 in gene PARK2/PACRG with leprosy

7. Mutation of PACRG was not identified as a cause of male infertility, but variation in the promoter was demonstrated to be a risk factor associated with azoospermia.

8. PINK1, Omi/HtrA2 and parkin participate at different levels in mitochondrial quality control, converging through some overlapping and some distinct steps to maintain a common phenotype of healthy mitochondrial networks [REVIEW]

9. PACRG is linked to parkin via a bi-directional promoter

10. Glup/PACRG forms a large molecular chaperone complex, suppresses cell death induced by accumulation of unfolded Pael receptor, facilitates the formation of Pael-R inclusions,and is a component of Lewy bodies in Parkinson's disease

11. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy

12. mutation of PACRG plays little or no role in the development of early-onset parkinsonism

13. candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm

14. Suspected association of SNP's with leprosy is not borne out in Indian population.

15. PACRG is regulated by the ubiquitin-proteasomal system and may play a role in the pathogenesis of Parkinson's disease.

16. The observed features of genotypic distribution by PACRG marker point to the influence of the considered marker on the incidence of tuberculosis.

17. Thw results of this study suggested that point mutations in PACRG are not a common cause of EO-PD but haploinsufficiency for PACRG may be associated with disease.

Mouse (Murine) PARK2 Co-Regulated (PACRG) interaction partners

1. Results show that aged single knockout Pacrg mouse and double knockout parkin-Pacrg mouse do not show behavioral or neuropathological deficits of the dopaminergic system. Collectively, these studies suggest that gene mediated deficiency in the mouse may alter pathways common to human pathogenesis but for as yet unknown reasons do not cause a pronounced Parkinson disease-like phenotype.

2. Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella.

3. Pacrg is required for motile cilia function and may be involved in the pathogenesis of hydrocephalus.

4. Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis.

5. PACRG is linked to parkin via a bi-directional promoter [PACRG]

6. The quaking mutation is a deletion of approximately 1.17 Mb of mouse chromosome 17, resulting in the deletion of the entire promoter and first five coding exons of PRKN. The recently described Parkin Co-Regulated Gene (PACRG) is completely deleted.

7. Results demonstrate that the deletion of Pacrg (PARKIN-coregulated gene) is the cause of male sterility in the Quaking(viable) (qk(v)) mutant mouse.

8. These results suggest that the transcriptional co-regulation of Pacrg and parkin leads to a similar regional protein distribution in mouse brain, which may have functional significance for the two proteins.

9. The results of this study indicated that expression of Pacrg in the cells associated with the cerebral ventricle, in addition to the aqueduct of Sylvius and choroid plexus. And strong expression was observed since newborn period to adulthood.

10. Pacrg is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.