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Mapping of the PARK2 and PACRG gene regulatory region with 96 SNPs, with a resolution of 1 SNP per 1 Kb for PARK2 gene regulatory region in a North Indian population, showed an involvement of 11 SNPs in determining the susceptibility towards leprosy.
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PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome.
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conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families
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Elevated levels of PACRG result in increased neuronal autophagy.
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single nucleotide polymorphisms of PARK2 with leprosy susceptibility in Chinese population
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the association of polymorphisms rs9356058 and rs1040079 in gene PARK2/PACRG with leprosy
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Mutation of PACRG was not identified as a cause of male infertility, but variation in the promoter was demonstrated to be a risk factor associated with azoospermia.
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PINK1, Omi/HtrA2 and parkin participate at different levels in mitochondrial quality control, converging through some overlapping and some distinct steps to maintain a common phenotype of healthy mitochondrial networks [REVIEW]
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PACRG is linked to parkin via a bi-directional promoter
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Glup/PACRG forms a large molecular chaperone complex, suppresses cell death induced by accumulation of unfolded Pael receptor, facilitates the formation of Pael-R inclusions,and is a component of Lewy bodies in Parkinson's disease
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Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy
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mutation of PACRG plays little or no role in the development of early-onset parkinsonism
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candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm
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Suspected association of SNP's with leprosy is not borne out in Indian population.
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PACRG is regulated by the ubiquitin-proteasomal system and may play a role in the pathogenesis of Parkinson's disease.
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The observed features of genotypic distribution by PACRG marker point to the influence of the considered marker on the incidence of tuberculosis.
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Thw results of this study suggested that point mutations in PACRG are not a common cause of EO-PD but haploinsufficiency for PACRG may be associated with disease.