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Modulates chromatin structure. Additionally we are shipping PHD Finger Protein 13 Antibodies (40) and many more products for this protein.
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High SPOC1 expression is associated with Cytomegalovirus infections.
PHF13 has opposing effects throughout the HIV-1 replication cycle (figure 8). After viral entry and nuclear import of the PIC, PHF13 can increase the number of integrated HIV-1 proviral genomes. After integration, PHF13 acts as antiviral restriction factor and inhibits viral gene expression.
These experiments showed that PHF13 binds specifically to DNA and to two types of histone H3 (show HIST3H3 Proteins) methyl tags (lysine 4-tri (show VANGL2 Proteins)-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator.
SPOC1-mediated restriction imposed upon Ad growth is relieved by its functional association with the Ad major core protein pVII that enters with the viral genome, followed by E1B (show BCKDHB Proteins)-55K/E4orf6-dependent proteasomal degradation of SPOC1.
SPOC1 modulates chromatin structure and that tight regulation of its expression levels and subcellular localization during mitosis are crucial for proper chromosome condensation and cell division.
Rods fail to robustly accumulate active ATM (show ATM Proteins) at DNA double-strand breakd, exhibit low KAP1 (show TRIM28 Proteins) levels, and display high levels of SPOC1, a factor suppressing KAP1 (show TRIM28 Proteins) phosphorylation. This results in dramatically reduced KAP1 (show TRIM28 Proteins) phosphorylation.
Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.
PHD zinc finger protein PHF5
, survival time-associated PHD finger protein in ovarian cancer 1
, survival time-associated PHD protein in ovarian cancer