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The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. Additionally we are shipping PHF8 Antibodies (35) and PHF8 Proteins (6) and many more products for this protein.
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PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP (show SCP2 ELISA Kits)) in the hippocampus.
knockdown of pmaip1 (show PMAIP1 ELISA Kits) mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.
The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation.
an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate
These findings suggested that PHF8 played an oncogenic role in facilitating FIP200-dependent autophagic degradation of E-cadherin, EMT and metastasis in hepatocellular carcinoma (HCC). PHF8 might be a promising target for prevention, treatment and prognostic prediction of HCC.
the PHF8 oncogene (show RAB1A ELISA Kits) is involved in the progression of CRC (show CALR ELISA Kits). The preliminary findings indicated that PHF8, as a potential target of miR (show MLXIP ELISA Kits)-488, can be suppressed by the overexpression of miR (show MLXIP ELISA Kits)-488. Low levels of miR (show MLXIP ELISA Kits)-488 and high levels of PHF8 were correlated with poor overall survival rates in patients with CRC (show CALR ELISA Kits).
PIP2-binding mutant of PHF8 has increased the activity of rDNA promoter (20%) and expression of pre-rRNA genes (47S-100%; 45S-66%).
Our data reveal novel mechanisms that underlie the regulation of PHF8 and KDM3A during NED and in CRPC, and support the candidacy of PHF8 as a therapeutic target in CRPC.
Thus, PHF8 forms a positive feedback loop with the MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) pathway, and PHF8 knockdown enhances the lethality of PD184352 in ALL cells. In conclusion, this study identifies oncogenic functions of PHF8 in adult ALL and suggests a novel epigenetic strategy for disease intervention.
Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha (show HIF1A ELISA Kits).
USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 (show CCNA2 ELISA Kits). and the interaction between USP7 and PHF8 is augmented during DNA damage.
PHF8 reduces the H3K9me2 level at the E2F4 transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 gene regulation
PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
PHF8 promotes lung cancer cell growth and survival by regulating miR-21.
PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
histone lysine demethylase PHF8
, jumonji C domain-containing histone demethylase 1F