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POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. Additionally we are shipping POU Class 6 Homeobox 2 Proteins (5) and many more products for this protein.
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Human Polyclonal POU6F2 Primary Antibody for ELISA, WB - ABIN4346896
Perotti, De Vecchi, Testi, Lualdi, Modena, Mondini, Ravagnani, Collini, Di Renzo, Spreafico, Terenziani, Sozzi, Fossati-Bellani, Radice: Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. in Human mutation 2004
We further discovered that the expression of transcription factor POU class 6 homeobox 2 (POU6F2) is restricted to Corneal endothelial cells (CECs) , and upregulated during human CEC differentiation, suggesting that POU6F2 is pivotal to terminal differentiation of CECs
Genomic loci were examined in the NEIGHBORHOOD database to determine if they are potential risk factors for human glaucoma identified using meta-data from human GWAS. The top 50 hits all resided within one gene (POU6F2), with the highest significance level of p = 10-6 for SNP rs76319873. POU6F2 is found in retinal ganglion cells and in corneal limbal stem cells.
Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development
observations suggest that POU6F2 is a tumor suppressor and is involved in hereditary predisposition to Wilms tumor
Pou6F2 null mice have a corneal thinner than those of wild type littermates. Pou6F2 null retinal ganglion cells die early in the glaucoma model than most retinal ganglion cells.
mutations in the zinc-binding domain of Apobec2 (show APOBEC2 Antibodies) diminish its ability to stimulate Pou6f2 binding to DNA, and knockdown of Ubc9 (show UBE2I Antibodies) or Pou6f2 suppressed retina regeneration
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
POU domain, class 6, transcription factor 2
, Wilms tumor suppressor locus
, retina-derived POU domain factor 1
, retina-derived POU-domain factor-1
, POU class 6 homeobox 2