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PSMC3IP encodes a protein that functions in meiotic recombination. Additionally we are shipping PSMC3 Interacting Protein Antibodies (18) and PSMC3 Interacting Protein Proteins (5) and many more products for this protein.
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HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Results show the role of a coiled-coil structural feature involved in HOP2 self-association.
Authors propose that HOP2 may act as a recombinase with specific functions in meiosis.
C-terminal basic region of TBPIP/HOP2 is required for efficient DNA binding and is also essential for its homologous pairing stimulation activity
data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis
Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
The PSMC3IP mutation provides additional evidence that mutations in meiotic homologous recombination and DNA repair genes result in distinct female and male reproductive phenotypes, including delayed puberty and primary amenorrhea caused by Primary ovarian insufficiency (XX gonadal dysgenesis) in females but isolated azoospermia with normal pubertal development in males.
PSMC3IP gene mutations are not common causes of primary ovarian insufficiency in this Swedish cohort.
GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian cancer stroma.
a PSMC3IP/HOP2 mutation may cause XX ovarian dysgenesis through abolishing coactivation of estrogen-driven transcription
Data suggest that the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis.
findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP.
Identification of GT198 (TBPIP/Hop2) as a nuclear receptor coactivator. GT198 is phosphorylation regulated. GT198 interacts with nuclear receptors.
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants.
homologous-pairing protein 2 homolog
, Homologous-pairing protein 2 homolog
, PSMC3 interacting protein
, PSMC3-interacting protein
, TBP-1-interacting protein
, proteasome 26S ATPase subunit 3-interacting protein
, tat-binding protein 1-interacting protein
, nuclear receptor coactivator GT198
, proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein