anti-Paired Box 1 (PAX1) Antibodies

Human Paired Box 1 (PAX1) interaction partners

1. Here we report a third family of OTFCS2 phenotype wherein whole exome sequencing identified a novel homozygous small insertion in PAX1 as the underlying genetic cause.

2. Hypermethylated ZNF582 and PAX1 genes in oral epithelial cells collected by mouth rinse are effective biomarkers for the detection of oral dysplasia and oral cancer.

3. Both PAX1 rs17861031 and rs6137473 were significantly associated with AIS and different PUMC classifications of AIS in a northern Chinese Han population.

4. The association between PAX1 and the susceptibility of AIS was successfully replicated in the Chinese population

5. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC

6. A novel PAX1 null homozygous mutation in autosomal recessive otofaciocervical syndrome associated with severe combined immunodeficiency has been described in a consanguineous family.

7. PAX1 gene methylation was associated with the transition of CIN I to CIN II/III and CIN II/III to cervical cancer, so that it could be an auxiliary biomarker to estimate the risk of CIN progress.

8. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence

9. DNA methylation status of PAX1 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA.

10. Paired boxed gene 1 protein expression is a potential histopathology biomarker for the differential diagnosis of malignant and premalignant endometrial lesions. Paired boxed gene 1 is also a potential prognostic marker in cases of endometrial carcinoma.

11. Hypermethylation of PAX1 gene may be highly associated with the development of cervical cancer.

12. meta-analysis support the utility of PAX1 methylation as an auxiliary biomarker in cervical cancer screening

13. Testing PAX1 DNA methylation using oral swabs is a promising method for oral cancer detection. Combined assessments regarding betel nut consumption and DNA methylation can improve OSCC screening

14. PAX1 methylation hallmarks a potential diagnostic value for cervical cancer screening in Asians

15. analysis of a PAX1 enhancer locus that is associated with susceptibility to idiopathic scoliosis in females

16. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis.

17. PAX1 methylation is associated with cervical cancer.

18. PAX1 methylation is associated with high-grade squamous intraepithelial lesions.

19. Cervical adenocarcinoma cells carry aberrantly high methylation rates of PAX1, commonly methylated in squamous cell carcinomas.

20. We identified PAX1 as a novel disease-causing gene for otofaciocervical syndrome and show that the pooling of DNA from affected individuals can reduce the number of putative disease-causing homozygous variants in consanguineous families.

Xenopus laevis Paired Box 1 (PAX1) interaction partners

1. Cloning and examination through whole-mount in situ hybridization and reverse transcriptase-polymerase chain reaction of the expression patterns of pax1, pax9, and uncx transcription factors in the anuran Xenopus laevis.

Mouse (Murine) Paired Box 1 (PAX1) interaction partners

1. Pax1 and Pax9 can transactivate regulatory sequences in the Bapx1 promoter to induce chondrogenic differentiation in the sclerotome.

2. Adult mice which carry a new allele of Pax1 have a lumbar scoliosis and kinky tails, a models for scoliosis

3. In addition to Hoxa3, this protein is required for both epithelial cell growth and differentiation throughout thymus and parathyroid organogenesis.