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PAX1 is a member of the paired box (PAX) family of transcription factors.
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A novel PAX1 null homozygous mutation in autosomal recessive otofaciocervical syndrome associated with severe combined immunodeficiency (show PRKDC Antibodies) has been described in a consanguineous family.
PAX1 gene methylation was associated with the transition of CIN (show PDXP Antibodies) I to CIN (show PDXP Antibodies) II/III and CIN (show PDXP Antibodies) II/III to cervical cancer, so that it could be an auxiliary biomarker to estimate the risk of CIN (show PDXP Antibodies) progress.
conclude that hypermethylated ZNF582 (show ZNF582 Antibodies) and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence
DNA methylation (show HELLS Antibodies) status of PAX1 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA.
Hypermethylation of PAX1 gene may be highly associated with the development of cervical cancer.
meta-analysis support the utility of PAX1 methylation as an auxiliary biomarker in cervical cancer screening
Testing PAX1 DNA methylation (show HELLS Antibodies) using oral swabs is a promising method for oral cancer detection. Combined assessments regarding betel nut consumption and DNA methylation (show HELLS Antibodies) can improve OSCC screening
PAX1 methylation hallmarks a potential diagnostic value for cervical cancer screening in Asians
analysis of a PAX1 enhancer locus that is associated with susceptibility to idiopathic scoliosis in females
PAX1 and SOX1 (show SOX1 Antibodies) DNA methylation (show HELLS Antibodies) correlate with a cervical intraepithelial neoplasia diagnosis.
Cloning and examination through whole-mount in situ hybridization and reverse transcriptase-polymerase chain reaction of the expression patterns of pax1, pax9, and uncx transcription factors in the anuran Xenopus laevis.
Pax1 and Pax9 (show PAX9 Antibodies) can transactivate regulatory sequences in the Bapx1 (show NKX3-2 Antibodies) promoter to induce chondrogenic differentiation in the sclerotome.
Adult mice which carry a new allele of Pax1 have a lumbar scoliosis and kinky (show AXIN1 Antibodies) tails, a models for scoliosis
In addition to Hoxa3 (show HOXA3 Antibodies), this protein is required for both epithelial cell growth and differentiation throughout thymus and parathyroid organogenesis.
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations.
paired box 1
, paired box gene 1
, paired box protein Pax-1-like
, paired box protein Pax-1
, paired domain gene HuP48
, Paired box homeotic gene 1
, paired box protein 1
, paired box transcription factor
, wavy tail