Paired Immunoglobin-Like Type 2 Receptor beta Proteins (PILRB)

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known.

• paired immunoglobin-like type 2 receptor beta (PILRB)
• paired immunoglobin-like type 2 receptor beta 1 (Pilrb1)
• paired immunoglobin-like type 2 receptor beta (Pilrb)

• Fdact protein
• FDFACT protein
• FDFACT1 protein
• FDFACT2 protein
• Pilrb protein

activating receptor PILR-beta , activating receptor PILRbeta , cell surface receptor FDFACT , cell surface receptor FDFACT1 , cell surface receptor FDFACT2 , paired immunoglobin-like receptor beta , paired immunoglobulin-like receptor beta , paired immunoglobulin-like type 2 receptor beta , immunoglobulin-like cell surface receptor FDFACT, activating counterpart