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The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. Additionally we are shipping Paired Immunoglobin-Like Type 2 Receptor beta Antibodies (26) and Paired Immunoglobin-Like Type 2 Receptor beta Kits (7) and many more products for this protein.
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Characterization of paired counterpart PILRA (show PILRA Proteins).
Data show that PILRbeta is important for regulating aberrant inflammatory responses through IL-27 (show IL27 Proteins) production.
Activation of PILRa (show PILRA Proteins) or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known.
activating receptor PILR-beta
, activating receptor PILRbeta
, cell surface receptor FDFACT
, cell surface receptor FDFACT1
, cell surface receptor FDFACT2
, paired immunoglobin-like receptor beta
, paired immunoglobulin-like receptor beta
, paired immunoglobulin-like type 2 receptor beta
, immunoglobulin-like cell surface receptor FDFACT, activating counterpart