Paired-Like Homeobox 2a Proteins (PHOX2A)

The protein encoded by PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. Additionally we are shipping Paired-Like Homeobox 2a Antibodies (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHOX2A 401 O14813
PHOX2A 11859 Q62066
Rat PHOX2A PHOX2A 116648 Q62782
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Top Paired-Like Homeobox 2a Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

PHOX2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Paired-Like Homeobox 2a (PHOX2A) Interaction Partners

Human Paired-Like Homeobox 2a (PHOX2A) interaction partners

  1. PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B (show PHOX2B Proteins) down-regulation.

  2. Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene.

  3. Patients with ARIX and/or PHOX2B (show PHOX2B Proteins) polymorphisms had less hypoplastic superior oblique muscles.

  4. The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase (show DBH Proteins) gene transcription through its phosphorylation status

  5. PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2)

  6. the polymorphisms of the ARIX gene and PHOX2B (show PHOX2B Proteins) gene may be genetic risk factors for the development of congenital superior oblique muscle palsy

  7. PHOX2A, but not PHOX2B (show PHOX2B Proteins), seems to act directly on the c-RET (show RET Proteins) promoter

  8. Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor.

  9. These results demonstrate the direct interactions of the Phox2a and b and dHAND (show HAND2 Proteins) transcription factors within a noradrenergic cell type

  10. the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins.

Mouse (Murine) Paired-Like Homeobox 2a (PHOX2A) interaction partners

  1. All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1 (show ISL1 Proteins)-Lhx3 (show LHX3 Proteins) complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals

  2. reveal an unanticipated role for Lmx1b (show LMX1B Proteins) in regulating Phox2a expression and the sequential specification of ocular motor neurons (OMNs) and red nucleus neurons (RNNs) from progenitors located lateral to dopamine neurons in the midbrain

  3. Maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b (show PHOX2B Proteins) in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus.

  4. Noradrenaline, A6 neurons, and the Phox2a gene, which is crucial for the generation of A6 neurons, are essential for development of normal respiratory rhythm in neonatal mice

  5. Phox2 genes have roles in neural differentiation

  6. These data indicate that Phox2a plays a critical role in the ontogeny of the reflex control of inspiration.

Paired-Like Homeobox 2a (PHOX2A) Protein Profile

Protein Summary

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

Gene names and symbols associated with PHOX2A

  • paired like homeobox 2a (PHOX2A)
  • paired-like homeobox 2a (Phox2a)
  • paired-like homeobox 2a (phox2a)
  • paired like homeobox 2a S homeolog (phox2a.S)
  • paired-like homeobox 2a (PHOX2A)
  • arix protein
  • CFEOM2 protein
  • FEOM2 protein
  • NCAM2 protein
  • phox2 protein
  • Pmx2 protein
  • Pmx2a protein
  • sou protein
  • xphox2a protein
  • zgc:77364 protein

Protein level used designations for PHOX2A

ARIX1 homeodomain protein , aristaless homeobox homolog , aristaless homeobox protein homolog , arix homeodomain protein , paired mesoderm homeobox protein 2A , PHOX2A homeodomain protein , aristaless homeobox gene homolog , paired mesoderm homeobox 2a , aristaless homeobox , soulless , paired-like (aristaless) homeobox 2a

401 Homo sapiens
11859 Mus musculus
116648 Rattus norvegicus
404602 Danio rerio
402788 Xenopus laevis
395595 Gallus gallus
485208 Canis lupus familiaris
507670 Bos taurus
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