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PHOX2A Products

(Paired-Like Homeobox 2a (PHOX2A))

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The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008].

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Featured PHOX2A Categories

PHOX2A Antibodies

High quality antibodies with extensive validation data.

PHOX2A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PHOX2A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (5)
Cat. No. ABIN559952
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN2565772
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7162523
Quantity 100 μg
Datasheet Datasheet

Recommended PHOX2A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314942
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314944
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3086044
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PHOX2A products

Fan, Huang, Kieran, Zhu: "Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells." in: Journal of neurochemistry, Vol. 110, Issue 5, pp. 1502-13, (2009) (PubMed).

Adachi, Lewis: "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22915-24, (2002) (PubMed).

Pinkoski, Waterhouse, Heibein, Wolf, Kuwana, Goldstein, Newmeyer, Bleackley, Green: "Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 12060-7, (2001) (PubMed).

Rotonda, Garcia-Calvo, Bull, Geissler, McKeever, Willoughby, Thornberry, Becker: "The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1." in: Chemistry & biology, Vol. 8, Issue 4, pp. 357-68, (2001) (PubMed).

Sharif-Askari, Alam, Rhéaume, Beresford, Scotto, Sharma, Lee, DeWolf, Nuttall, Lieberman, Sékaly: "Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation." in: The EMBO journal, Vol. 20, Issue 12, pp. 3101-13, (2001) (PubMed).

Barry, Heibein, Pinkoski, Lee, Moyer, Green, Bleackley: "Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid." in: Molecular and cellular biology, Vol. 20, Issue 11, pp. 3781-94, (2000) (PubMed).

Beresford, Xia, Greenberg, Lieberman: "Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation." in: Immunity, Vol. 10, Issue 5, pp. 585-94, (1999) (PubMed).

Shresta, Graubert, Thomas, Raptis, Ley: "Granzyme A initiates an alternative pathway for granule-mediated apoptosis." in: Immunity, Vol. 10, Issue 5, pp. 595-605, (1999) (PubMed).

Synonyms and alternative names related to PHOX2A

paired like homeobox 2a (PHOX2A), paired-like homeobox 2a (Phox2a), paired-like homeobox 2a (phox2a), paired like homeobox 2a S homeolog (phox2a.S), paired-like homeobox 2a (PHOX2A), ARIX, Arix, arix, CFEOM2, FEOM2, NCAM2, Phox2, phox2, Pmx2, PMX2A, Pmx2a, sou, xphox2a, zgc:77364

Protein level used designations for PHOX2A

  • ARIX1 homeodomain protein
  • aristaless homeobox homolog
  • aristaless homeobox protein homolog
  • arix homeodomain protein
  • paired mesoderm homeobox protein 2A
  • PHOX2A homeodomain protein
  • aristaless homeobox gene homolog
  • paired mesoderm homeobox 2a
  • aristaless homeobox
  • soulless
  • paired-like (aristaless) homeobox 2a
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