Paraoxonase 2 (PON2) ELISA Kits

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. Additionally we are shipping PON2 Antibodies (131) and PON2 Proteins (17) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PON2 5445 Q15165
PON2 330260 Q62086
PON2 296851 Q6AXM8
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Top PON2 ELISA Kits at

Showing 6 out of 29 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.32 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests Log in to see 13 to 16 Days
Mouse 0.052 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
Cow 19.5 pg/mL 78.1-5000 pg/mL   96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 2 to 3 Days
  96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days

More ELISA Kits for PON2 Interaction Partners

Human Paraoxonase 2 (PON2) interaction partners

  1. Microarray analysis revealed differential expression of three vitamin D associated genes in the aortic adventitia in rheumatoid arthritis (RA) and non-RA patients with coronary artery disease: while the expression of GADD45A and NCOR1 was higher, the expression of PON2 was lower in RA patients.

  2. In donor retina from patients with diabetes, all three PON1, PON2 and PON3 were expressed, and there was a significant increase in PON3 expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control

  3. The decrease in monocyte/macrophage PON2 enzymatic activity observed in type 2 diabetes cannot be totally explained by abdominal obesity and insulin resistance.

  4. these results showed that PON2 could represent a molecular biomarker for bladder cancer and suggest a potential role of the enzyme as a prognostic factor for this neoplasm

  5. Study observed a genetic effect in ischemic stroke patients of the north area of the Gran Canaria island linked to the rs7493 variant in the PON2 gene with worse atherogenic ultrasonographic profile in ischemic stroke patients. Conversely, the Cys311Cys homozygosity, which is usually associated with an increased risk of stroke in the general population, was also related to a better ultrasonographic profile.

  6. Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower Reactive Oxygen Species levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells.

  7. PON2 is a new potential biomarker for therapy resistance or a prognostic tumor marker.

  8. PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression

  9. Paraoxonase 2 facilitates pancreatic ductal cancer growth and metastasis by stimulating GLUT1-mediated glucose transport.

  10. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS) production and induces Bim protein production that inhibits cancer progression via the PON2-Bim cascade.

  11. Data suggest that paraoxonases (PON1, PON2, PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 activities are associated with poor survival in patients with severe sepsis. [REVIEW]

  12. Data show that the mRNA levels of both paraoxonases PON2 and PON3 were significantly upregulated whereas PON1's mRNA was absent in transgenic mouse hearts.

  13. High soluble expression levels were achieved with a yield of 76 mg of fully human PON2 variants per liter of culture media

  14. The PON2 Ser311Cys polymorphism is associated with coronary heart disease risk in Caucasians.

  15. Thi study found that the CC genotype of the PON2 S311C polymorphism is a risk factor for ischemic stroke.

  16. Studies indicate that three paraoxonases PON1, PON2, and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.

  17. PON2 SNPs rs12026 and rs7493 were associated with intracerebral hemorrhage. The C alleles of rs12026 and rs7493 contributed to a decreased risk of ICH.

  18. Data indicate the relationship between ubiqutination of lysine (Lys) 168 and paraoxonase 2 (PON2) catalytic activity.

  19. Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1, PON2, PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL level in blood. [REVIEW]

  20. Haplotype containing two risk alleles of PON1 and PON2 genes was significantly associated with disease diabetes mellitus, type 2.

Mouse (Murine) Paraoxonase 2 (PON2) interaction partners

  1. PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression

  2. PON2 plays an important role in innate immune defense against Pseudomonas aeruginosa infection.

  3. macrophage triglyceride accumulation upregulates PON2 expression via MEK/ JNK/c-Jun pathway, and these effects could be related, at least in part, to cellular triglycerides-induced ROS formation.

  4. These results suggest that PON2 is a novel major intracellular factor that protects CNS cells against oxidative stress and confers gender-dependent susceptibility to such stress

  5. Macrophage PON2 modulates mechanisms that link endoplasmic reticulum stress, mitochondrial dysfunction and the development of atherosclerosis.

  6. expression in brain regions and protection against oxidative-stress-mediated neurotoxicity

  7. results demonstrate that PON2 plays an important role in hepatic insulin signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin sensitivity.

  8. Results illustrate that the antiatherogenic effects of PON2 are, in part, mediated by the role of PON2 in mitochondrial function.

  9. Under normal conditions macrophage endoplasmic reticulum stabilizes PON2 activity, and this effect could be attributed to ER proteins and redox status.

  10. PON2 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

  11. Pomegranite juice consumption antioxidative properties on mouse macrophages are mediated via PJ-induced stimulation of macrophage PON2 expression.

  12. analysis of macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice

  13. PON2 decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity

  14. Increased macrophage PON2 expression under oxidative stress could represent a selective cellular response to reduce oxidative burden, which may lead to attenuation of macrophage foam cell formation.

  15. PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis

  16. biphasic effect of oxidative stress on macrophage PON2 activity could be related to PON2 inactivation (decreased enzymatic activity) under oxidative stress induction at its low range

  17. role in airway epithelial cell inactivation of N-3-oxododecanoyl homoserine lactone; findings show that that Pseudomonas aeruginosa quorum sensing was enhanced in PON2-deficient airway epithelia

  18. macrophages from diabetic mice demonstrate increased oxidative stress and up-regulation of cellular PON2

  19. Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism.

  20. The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.

Pig (Porcine) Paraoxonase 2 (PON2) interaction partners

  1. The expression of the PON2 gene was greater in Meishan pig than that in Yorkshire on gestational day 26 and 90.

Cow (Bovine) Paraoxonase 2 (PON2) interaction partners

  1. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

PON2 Antigen Profile

Antigen Summary

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with Paraoxonase 2 (PON2) ELISA Kits

  • serum paraoxonase/arylesterase 2 (LOC100303695) antibody
  • paraoxonase 2 (PON2) antibody
  • paraoxonase 2 L homeolog (pon2.L) antibody
  • serum paraoxonase/arylesterase 2 (BDBG_00600) antibody
  • Serum paraoxonase/arylesterase 2 (pon2) antibody
  • paraoxonase 2 (Pon2) antibody
  • 6330405I24Rik antibody
  • AI481612 antibody
  • MGC53915 antibody
  • pon1 antibody
  • pon2 antibody

Protein level used designations for Paraoxonase 2 (PON2) ELISA Kits

A-esterase 2 , Aromatic esterase 2 , PON 2 , Serum aryldialkylphosphatase 2 , Serum paraoxonase/arylesterase 2 , paraoxonase 2 , celiac disease 2 , serum paraoxonase/arylesterase 2-like , serum paraoxonase/arylesterase 2 , aromatic esterase 2 , paraoxonase nirs , serum aryldialkylphosphatase 2

100303695 Meleagris gallopavo
463549 Pan troglodytes
100145861 Ovis aries
100218152 Taeniopygia guttata
100340152 Oryctolagus cuniculus
100407939 Callithrix jacchus
380341 Xenopus laevis
8507698 Ajellomyces dermatitidis SLH14081
100196477 Salmo salar
5445 Homo sapiens
330260 Mus musculus
296851 Rattus norvegicus
403855 Canis lupus familiaris
100142663 Sus scrofa
281417 Bos taurus
395830 Gallus gallus
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