anti-Patatin-Like phospholipase Domain Containing 8 (PNPLA8) Antibodies

PNPLA8 encodes a member of the patatin-like phospholipase domain containing protein family. Additionally we are shipping Patatin-Like phospholipase Domain Containing 8 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPLA8 50640 Q9NP80
PNPLA8 67452 Q8K1N1
PNPLA8 314075  
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Top anti-Patatin-Like phospholipase Domain Containing 8 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PNPLA8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of PNPLA8 expression in A549 (A), HeLa (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/HeLa/A549 cells, using PNPLA8 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from HeLa cells using PNPLA8 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6274936 staining  HuvEc cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis in Hela,K562 cell line lysates (35ug/lane). Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB PNPLA8 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL 11 to 14 Days
$390.50
Details

Top referenced anti-Patatin-Like phospholipase Domain Containing 8 Antibodies

  1. Human Polyclonal PNPLA8 Primary Antibody for ICC, IF - ABIN4346574 : Pattabiraman, Lih, Tomer, Rao: The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. in American journal of physiology. Cell physiology 2012 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal PNPLA8 Primary Antibody for WB - ABIN2786886 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Patatin-Like phospholipase Domain Containing 8 Interaction Partners

Human Patatin-Like phospholipase Domain Containing 8 (PNPLA8) interaction partners

  1. we report two unrelated individuals with variable but similar clinical features of microcephaly, severe global developmental delay, spasticity, lactic acidosis, and progressive cerebellar atrophy with biallelic loss-of-function variants in PNPLA8.

  2. Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels AA into toxic HETEs. These results mechanistically identify the sequelae of pathological remodeling of human mitochondrial phospholipases in failing myocardium.

  3. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation.

  4. iPLA2gamma plays a cardioprotective role during the acute stage of Chagas' disease.

  5. Thus, complement-mediated activation of iPLA(2)gamma is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)gamma.

  6. These results suggest distinct roles for iPLA2beta and iPLA2gamma in cellular homeostasis and signaling, a functional link between peroxisomal AA release and eicosanoid generation, and a potential contribution of iPLA2gamma to tumorigenesis.

  7. iPLA2 activation is not sufficient for SOCE activation. iPLA2 may regulate basal phosphoinositide metabolism

Mouse (Murine) Patatin-Like phospholipase Domain Containing 8 (PNPLA8) interaction partners

  1. over-expression of PNPLA8 dramatically decreases hepatic steatosis through increased autophagy in hepatocytes of high-fat diet-fed mice

  2. these results demonstrate the integrated roles of Cardiolipin and iPLA2gamma in lipid second-messenger production and mitochondrial bioenergetics during oxidative stress.

  3. Because mitochondrial membrane depolarization and calcium are known to activate iPLA2gamma, these results are consistent with salvage of myocardium after Ischemia/Reperfusion by iPLA2gamma loss of function through decreasing mPTP opening, diminishing production of proinflammatory oxidized fatty acids

  4. UCP2, functional due to fatty acids released by redox-activated mt-iPLA2gamma, suppresses mitochondrial superoxide production by its uncoupling action.

  5. Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice

  6. iPLA(2)beta and iPLA(2)gamma are required for the adipogenic program that drives resting 3T3-L1 cells into adipocytes after hormone stimulation

  7. iPLA2 signaling plays an important role in glucose-stimulated insulin secretion under physiological conditions

  8. iPLA(2)gamma is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition

  9. the obligatory role of iPLA(2)gamma in neuronal mitochondrial lipid metabolism and membrane structure demonstrating that iPLA(2)gamma loss of function results in a mitochondrial neurodegenerative disorder

Patatin-Like phospholipase Domain Containing 8 (PNPLA8) Antigen Profile

Protein Summary

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PNPLA8

  • patatin like phospholipase domain containing 8 (PNPLA8) antibody
  • patatin-like phospholipase domain containing 8 (Pnpla8) antibody
  • 1200006O19Rik antibody
  • AI467579 antibody
  • iPLA2 antibody
  • Ipla2(gamma) antibody
  • IPLA2-2 antibody
  • IPLA2G antibody
  • iPLA2gamma antibody
  • RGD1311444 antibody

Protein level used designations for PNPLA8

PNPLA-gamma , calcium-independent phospholipase A2-gamma , iPLA2 gamma , iPLA2-gamma , intracellular membrane-associated calcium-independent phospholipase A2 gamma , membrane-associated calcium-independent phospholipase A2 gamma , patatin-like phospholipase domain-containing protein 8 , group VIB calcium-independent phospholipase A2

GENE ID SPECIES
50640 Homo sapiens
67452 Mus musculus
314075 Rattus norvegicus
100328577 Oryctolagus cuniculus
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