Patched Domain Containing 1 Proteins (PTCHD1)

PTCHD1 encodes a membrane protein with a patched domain. Additionally we are shipping PTCHD1 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTCHD1 139411 Q96NR3
PTCHD1 211612 Q14B62
Rat PTCHD1 PTCHD1 317517  
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Top PTCHD1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,506.65
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$10,699.55
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

PTCHD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Patched Domain Containing 1 (PTCHD1) Interaction Partners

Human Patched Domain Containing 1 (PTCHD1) interaction partners

  1. both common and rare PTCHD1 variants contribute to autism spectrum disorder.

  2. Our findings suggest that hemizygous PTCHD1 loss of function causes an X-linked neurodevelopmental disorder with a strong propensity to autistic behaviors.

  3. Deletion in Xp22.11: PTCHD1 is a candidate gene for X-linked intellectual disability with or without autism.

  4. Systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with autism spectrum disorder and intellectual disability.

Mouse (Murine) Patched Domain Containing 1 (PTCHD1) interaction partners

  1. Results support that PTCHD1 deficiency induces a neurodevelopmental disorder causing excitatory synaptic dysfunction.

  2. The Ptchd1 protein plays a critical role in the dentate gyrus and is associated with dendritic trafficking.

  3. thalamic reticular nucleus-restricted deletion of Ptchd1 leads to attention deficits and hyperactivity, both of which are rescued by pharmacological augmentation of small conductance calcium-dependent potassium channel activity

PTCHD1 Protein Profile

Protein Summary

This gene encodes a membrane protein with a patched domain. The encoded protein is similar to Drosophila proteins which act as receptors for the morphogen sonic hedgehog. Deletions in this gene, which is located on the X chromosome, are associated with intellectual disability and autism (PMID: 21091464, PMID: 20844286).

Gene names and symbols associated with PTCHD1

  • patched domain containing 1 (PTCHD1)
  • patched domain containing 1 (Ptchd1)
  • 9630036J22Rik protein
  • AI848149 protein
  • Gm387 protein
  • RGD1564527 protein

Protein level used designations for PTCHD1

patched domain-containing protein 1

GENE ID SPECIES
139411 Homo sapiens
491775 Canis lupus familiaris
536443 Bos taurus
211612 Mus musculus
317517 Rattus norvegicus
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