Peptidyl Arginine Deiminase, Type IV Proteins (PADI4)

PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. Additionally we are shipping PADI4 Antibodies (107) and PADI4 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PADI4 23569 Q9UM07
PADI4 18602 Q9Z183
PADI4 29512 O88807
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Top PADI4 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Baculovirus infected Insect Cells Human His tag,GST tag,GST tag 10 μg Log in to see 20 to 21 Days
$303.60
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Baculovirus infected Insect Cells Human His tag SDS-PAGE 50 μg Log in to see 20 to 21 Days
$547.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,934.33
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$672.00
Details

PADI4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for Peptidyl Arginine Deiminase, Type IV (PADI4) Interaction Partners

Human Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. PADI4 contributes to gastric tumorigenesis by upregulating CXCR2 (show CXCR2 Proteins), KRT14 (show KRT14 Proteins) and TNF-alpha (show TNF Proteins) expression.

  2. In this case-control study with sufficient sample size to detect associations, we observed that PADI4 SNPS rs11203367 and rs874881 do not significantly determine RA susceptibility

  3. SNPs of PADI4 may be a risk factor for airway abnormalities in RA.

  4. this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the rheumatoid arthritis incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.

  5. PADI4 contributes to the pathogenesis of RA by protecting FLSs from apoptosis. PADI4 suppresses p21 (show CDKN1A Proteins) transcription through altering histone H3 (show HIST3H3 Proteins) arginine modifications on p21 (show CDKN1A Proteins) promoter region.

  6. Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 epitopes in rheumatoid arthritis.

  7. No associations were found between clinical subtypes of JIA and PADI4 allele frequency. rs2240337 in the PADI4 gene was significantly associated with anti-cyclic citrullinated peptide antibody-positivity in juvenile idiopathic arthritis.

  8. The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated in a meta-analysis. The overall analysis indicated a significant association between the PADI4-104C/T polymorphism and RA risk in the Chinese population (T vs C: OR = 1.45, 95%CI = 1.18-1.78; TT vs CC: OR = 1.49, 95%CI = 1.24-1.80; TT vs CC+CT: OR = 1.28, 95%CI = 1.08-1.51; TT+CT vs CC: OR = 1.75, 95%CI = 1.30-2.37).

  9. Overexpression of PAD4 constrains the activity of EMT (show ITK Proteins) via suppressing Elk1 (show ELK1 Proteins) expression.

  10. Our study also demonstrated that PADI4 contributes to tumor metastasis by regulating the gene expression of insulin-like growth factor 1 (IGF1 (show IGF1 Proteins)) and WAS/WASL-interacting protein family member 1 (WIPF1 (show WIPF1 Proteins)).

Mouse (Murine) Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.

  2. a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.

  3. PADI4 exacerbates arthritis with diverse immunological modifications.

  4. Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.

  5. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression

  6. PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc (show MYC Proteins) expression.

  7. PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

  8. PAD4 is dispensable in this effector phase model of arthritis

  9. analysis of regulation of histone modification and chromatin structure by the p53 (show TP53 Proteins)-PADI4 pathway

  10. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

PADI4 Protein Profile

Protein Summary

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Gene names and symbols associated with PADI4

  • peptidyl arginine deiminase 4 (PADI4)
  • peptidyl arginine deiminase, type IV (Padi4)
  • peptidyl arginine deiminase 4 (Padi4)
  • PAD protein
  • Pad4 protein
  • PADI5 protein
  • Pdi4 protein
  • PDI5 protein

Protein level used designations for PADI4

peptidyl arginine deiminase, type IV , protein-arginine deiminase type-4-like , HL-60 PAD , PADI-H protein , peptidyl arginine deiminase, type V , protein-arginine deiminase type IV , protein-arginine deiminase type-4 , PAD type IV , peptidylarginine deiminase IV , PAD-R4 , peptidyl arginine deiminase, type 4 , peptidylarginine deiminase type alpha

GENE ID SPECIES
100026011 Monodelphis domestica
100049826 Equus caballus
100415489 Callithrix jacchus
100471129 Ailuropoda melanoleuca
100592291 Nomascus leucogenys
23569 Homo sapiens
18602 Mus musculus
456530 Pan troglodytes
29512 Rattus norvegicus
606921 Canis lupus familiaris
508161 Bos taurus
100524749 Sus scrofa
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