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The protein encoded by PSPN is a neurotrophic factor, belonging to the GDNF family.
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Results suggested that PSPN is a possible key regulator of oral squamous cell carcinoma (OSCC) progression via PSPN-RET (show RET Antibodies)-mitogen-activated protein kinase (show MAPK1 Antibodies) activation and that PSPN overexpression may have diagnostic potential for OSCC.
Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1 (show GFRA1 Antibodies)/RET (show RET Antibodies) receptor complex.
Persephin/GFRalpha4 is unable to recruit RET (show RET Antibodies) protein into lipid rafts.
The results obtained suggest the involvement of NTN (show NRTN Antibodies), PSP (show MSMB Antibodies), and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons.
Mice lacking Pspn by homologous recombination show normal development and behavior, but are hypersensitive to cerebral ischemia.
TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype
The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.