Phosphate Cytidylyltransferase 1, Choline, alpha Proteins (PCYT1A)

Controls phosphatidylcholine synthesis.. Additionally we are shipping Phosphate Cytidylyltransferase 1, Choline, alpha Antibodies (67) and Phosphate Cytidylyltransferase 1, Choline, alpha Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCYT1A 5130 P49585
PCYT1A 140544 P19836
PCYT1A 13026 P49586
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Top Phosphate Cytidylyltransferase 1, Choline, alpha Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
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Yeast Chinese Hamster His tag   1 mg Log in to see 60 to 71 Days
$3,004.83
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,004.83
Details

PCYT1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A) Interaction Partners

Human Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A) interaction partners

  1. There is no correlation between single PCYT1A rs712012 and PCYT1A rs7639752 polymorphisms and the incidence of intrauterine fetal death.

  2. PCYT1A mutations were identified in patients with isolated retinal dystrophy without any skeletal involvement from two Italian families.

  3. CCT contributes to phospholipid compositional homeostasis. [Review]

  4. PCYT1A-generated phosphatidylcholine has a role in the normal function of white adipose tissue and insulin action

  5. We report loss-of-function mutations in PCYT1A as the cause of spondylometaphyseal dysplasia with cone-rod dystrophy.

  6. Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy

  7. N-Methylaspartate induced nitric oxide synthase activation and nuclear factor-kB subunit p65 nuclear translocation in A549 cells were responsible for decreased CTP:phosphocholine cytidylyltransferase A expression

  8. Analyses showed genotype effects of PCYT1A genes on spina bifida risk, but did not show evidence of gene-nutrient. interactions.

Mouse (Murine) Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A) interaction partners

  1. The findings reported herein indicate that palmitate-induced cisternal endoplasmic reticulum expansion is dependent on the activation of XBP-1/CCTalpha-mediated phospholipid accumulation in RAW 264.7 cells.

  2. Data suggest that CTalpha is an important factor in hepatocyte proliferation in vitro; however, liver regeneration, DNA synthesis, and phosphatidylcholine biosynthesis after partial hepatectomy are not impaired in CTalpha(-/-) knockout mice.

  3. CaMKI vies with CRM1/exportin 1 for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta-CCTalpha complex is a key effector mechanism that drives nuclear CCTalpha translocation.

  4. This study illustrates, for the first time, the connection between the acute accumulation of farnesylated prelamin A and involvement of CCT-alpha in generating an nucleoplasmic reticulum.

  5. Enforced expression of either CK(alpha) or CCTalpha increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation.

  6. 14-3-3zeta controls CCTalpha nuclear import in response to calcium signals, thereby regulating mammalian phospholipid synthesis.

  7. activation during the S phase of the cell cycle is mediated by the transcription factor Sp1

  8. cyclin-dependent kinase 2 (CDK2) phosphorylation of Sp1 activates CTalpha transcription during S phase.

  9. hepatic CTalpha has a role in regulating both hepatic and systemic lipid and lipoprotein metabolism

  10. ssion of CCTalpha increases surfactant PtdCho synthesis without affecting surfactant protein levels but disrupts glycogen metabolism in differentiating type II cells via its regulatory domain

  11. a physiologically relevant phosphorylation site and docking domain within CCTalpha serve as targets for ERKs, resulting in inhibition of surfactant synthesis

  12. CCTalpha expression is required for early embryonic development.

  13. SCD1 deficiency specifically increases CTP:choline cytidylyltransferase activity by promoting its translocation into membrane and enhances phosphatidylcholine biosynthesis in liver

  14. CTP:phosphocholine cytidylyltransferase (CT) messenger RNA(mRNA) increased at S-M phase corresponding to an increase of Ets-1 protein mRNA and decrease of Net protein mRNA indicating that Net is an important endogenous repressor for CTalpha transcription

  15. These observations suggest a role for JNK kinases as negative regulators of phospholipid synthesis in murine lung epithelia.

  16. HDAC1 plays a critical role in CTalpha repression and that Sp1 and E2F may serve as key targets for HDAC1-mediated CTalpha repression in fibroblasts

  17. The studies demonstrate that developmental induction of surfactant phospholipid is due, at least in part, to transcriptional activation of the CCTalpha gene.

  18. CCTalpha was not required for the proliferation or differentiation of lung epithelia but was essential for the secretory component of phospholipid synthesis and critical for the proper formation of lamellar bodies and surfactant protein homeostasis.

  19. CaM, by antagonizing calpain, serves as a novel binding partner for CCTalpha that stabilizes the enzyme under proinflammatory stress

  20. When knock-out hepatocytes were infected with an adenovirus expressing CTalpha, apoAI-dependent PC efflux returned partially, whereas cholesterol efflux and ABCA1 levels were not restored to normal levels.

Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A) Protein Profile

Protein Summary

Controls phosphatidylcholine synthesis.

Gene names and symbols associated with PCYT1A

  • phosphate cytidylyltransferase 1, choline, alpha (PCYT1A)
  • phosphate cytidylyltransferase 1, choline, alpha (Pcyt1a)
  • phosphate cytidylyltransferase 1, choline, alpha L homeolog (pcyt1a.L)
  • phosphate cytidylyltransferase 1, choline, alpha (pcyt1a)
  • phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a)
  • phosphate cytidylyltransferase 1, choline, alpha a (pcyt1aa)
  • CCT-alpha protein
  • ccta protein
  • Cctalpha protein
  • CT protein
  • cta protein
  • CTalpha protein
  • CTP protein
  • Ctpct protein
  • Cttalpha protein
  • pcyt1 protein
  • zgc:110237 protein

Protein level used designations for PCYT1A

CCT A , CCT-alpha , CT A , CTP:phosphocholine cytidylyltransferase A , choline-phosphate cytidylyltransferase A , phosphorylcholine transferase A , CTP:phosphocholine cytidylyl transferase , CTP:phosphocholine cytidylyltransferase alpha , choline phosphate cytidylyltransferase 1 alpha , phosphate cytidylyltransferase 1, choline, alpha isoform , phosphate cytidylyltransferase 1, choline, alpha , choline-phosphate cytidylyltransferase A-like , CTP phosphocholine cytidylyl transferase , Phosphorylcholine transferase A

GENE ID SPECIES
5130 Homo sapiens
140544 Rattus norvegicus
424915 Gallus gallus
478600 Canis lupus familiaris
734348 Xenopus laevis
100060318 Equus caballus
100125779 Bos taurus
100380080 Xenopus (Silurana) tropicalis
100405078 Callithrix jacchus
100435111 Pongo abelii
100512194 Sus scrofa
13026 Mus musculus
100689303 Cricetulus griseus
550327 Danio rerio
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