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PCYT2 encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Additionally we are shipping PCYT2 Antibodies (45) and and many more products for this protein.
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differences in phosphorylation between Pcyt2 isoforms
Pcyt2 expression is responsive to tumor nutritional micro-environment, up-regulated in response to metabolic stress under conditions of serum deprivation.
The Pcyt2 promoter is driven by a functional CAAT box (-90/-73) and by negative (-385/-255) and positive regulatory elements (-255/-153) in the upstream regions.
EGR1 (show EGR1 Proteins) is an important transcriptional stimulator of the human PCYT2 and that conditions that modify EGR1 (show EGR1 Proteins) also affect the function of ECT and consequently PE synthesis
we conclude that NF-Y and YY1 (show YY1 Proteins) are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription.
The data identify Pcyt2 and membrane Phosphatidylethanolamine biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function.
hypertriglyceridemia that accompanies Pcyt2 deficiency is the result of multiple metabolic adaptations
data unambiguously establish that the TAG accumulation present in Pcyt2-deficient hepatocytes is a direct consequence of Pcyt2 gene deficiency and reduced functioning of the de novo Kennedy pathway
single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis
PE phospholipids, Pcyt2 deficiency generates compensatory changes in triglyceride and energy substrate metabolism, resulting in a progressive development of liver steatosis, hypertriglyceridemia, obesity, and insulin (show INS Proteins) resistance
Regulation of the mouse CTP (show PCYT1A Proteins): phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis
study of the importance of the CDP (show CUX1 Proteins)-ethanolamine pathway in controlling the molecular species composition of phosphatidylethanolamine via Phosphoethanolamine cytidylyltransferase knock-out
This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants.
, putative ethanolamine-phosphate cytidylyltransferase
, Ethanolamine-phosphate cytidylyltransferase
, CTP:phosphoethanolamine cytidylyltransferase
, phosphorylethanolamine transferase
, CTP:phopshoethanolamine cytidylyltransferase