Phosphate Cytidylyltransferase 2, Ethanolamine Proteins (PCYT2)

PCYT2 encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Additionally we are shipping PCYT2 Antibodies (49) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCYT2 5833 Q99447
PCYT2 68671 Q922E4
PCYT2 89841 O88637
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Top PCYT2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Escherichia coli (E. coli) Human His tag 50 μg 15 to 19 Days
$1,107.69
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$3,072.67
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Yeast Rat His tag   1 mg 60 to 71 Days
$3,120.33
Details

PCYT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Phosphate Cytidylyltransferase 2, Ethanolamine (PCYT2) Interaction Partners

Human Phosphate Cytidylyltransferase 2, Ethanolamine (PCYT2) interaction partners

  1. These results suggest that the N-terminal CT domain of hECT contributes to its catalytic reaction, but C-terminal CT domain does not.

  2. differences in phosphorylation between Pcyt2 isoforms

  3. Pcyt2 expression is responsive to tumor nutritional micro-environment, up-regulated in response to metabolic stress under conditions of serum deprivation.

  4. The Pcyt2 promoter is driven by a functional CAAT box (-90/-73) and by negative (-385/-255) and positive regulatory elements (-255/-153) in the upstream regions.

  5. EGR1 is an important transcriptional stimulator of the human PCYT2 and that conditions that modify EGR1 also affect the function of ECT and consequently PE synthesis

Mouse (Murine) Phosphate Cytidylyltransferase 2, Ethanolamine (PCYT2) interaction partners

  1. we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription.

  2. The data identify Pcyt2 and membrane Phosphatidylethanolamine biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function.

  3. The naturally occurring splice variant Pcyt2gamma has a function to restrain the enzyme activity through the formation of unproductive enzyme complexes.

  4. differences in phosphorylation between Pcyt2 isoforms

  5. hypertriglyceridemia that accompanies Pcyt2 deficiency is the result of multiple metabolic adaptations

  6. data unambiguously establish that the TAG accumulation present in Pcyt2-deficient hepatocytes is a direct consequence of Pcyt2 gene deficiency and reduced functioning of the de novo Kennedy pathway

  7. single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis

  8. alternative splicing of the mPcyt2 transcript is ubiquitous but could also be regulated in a tissue-specific manner, producing a variable ratio of mPcyt2alpha/mPcyt2beta mRNAs

  9. PE phospholipids, Pcyt2 deficiency generates compensatory changes in triglyceride and energy substrate metabolism, resulting in a progressive development of liver steatosis, hypertriglyceridemia, obesity, and insulin resistance

  10. Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis

  11. study of the importance of the CDP-ethanolamine pathway in controlling the molecular species composition of phosphatidylethanolamine via Phosphoethanolamine cytidylyltransferase knock-out

PCYT2 Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PCYT2

  • ethanolamine-phosphate cytidylyltransferase (Tc00.1047053511727.120)
  • ethanolamine-phosphate cytidylyltransferase (Tb11.01.5730)
  • ethanolamine-phosphate cytidylyltransferase (LINJ_32_0940)
  • ethanolamine-phosphate cytidylyltransferase (LOC5566800)
  • putative ethanolamine-phosphate cytidylyltransferase (LMJF_32_0890)
  • ethanolamine-phosphate cytidylyltransferase (EDI_013070)
  • ethanolamine-phosphate cytidylyltransferase (EDI_204270)
  • ethanolamine-phosphate cytidylyltransferase (CpipJ_CPIJ009320)
  • ethanolamine-phosphate cytidylyltransferase (Bm1_01855)
  • Ethanolamine-phosphate cytidylyltransferase (pcy2)
  • phosphate cytidylyltransferase 2, ethanolamine (PCYT2)
  • phosphate cytidylyltransferase 2, ethanolamine (Pcyt2)
  • phosphate cytidylyltransferase 2, ethanolamine L homeolog (pcyt2.L)
  • 1110033E03Rik protein
  • ET protein

Protein level used designations for PCYT2

ethanolamine-phosphate cytidylyltransferase , putative ethanolamine-phosphate cytidylyltransferase , Ethanolamine-phosphate cytidylyltransferase , CTP:phosphoethanolamine cytidylyltransferase , phosphorylethanolamine transferase , CTP:phopshoethanolamine cytidylyltransferase

GENE ID SPECIES
3551699 Trypanosoma cruzi strain CL Brener
3665178 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5071833 Leishmania infantum JPCM5
5566800 Aedes aegypti
5656202 Leishmania major strain Friedlin
5880432 Entamoeba dispar SAW760
5886247 Entamoeba dispar SAW760
6042098 Culex quinquefasciatus
6095325 Brugia malayi
100380284 Salmo salar
5833 Homo sapiens
68671 Mus musculus
444649 Xenopus laevis
510274 Bos taurus
89841 Rattus norvegicus
607608 Canis lupus familiaris
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