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Catalyzes the transfer of phosphatidylcholine between membranes. Additionally we are shipping PCTP Antibodies (51) and PCTP Kits (5) and many more products for this protein.
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Identified the variant rs2912553 as contributing to racially differential expression of PCTP.
Mutations in PCTP gene is associated with prostate cancer
PC-TP contributes to the racial difference in PAR4 (show PAWR Proteins)-mediated platelet activation.
crystal structures of human PC-TP in complex with dilinoleoyl-PtdCho or palmitoyl-linoleoyl-PtdCho reveal that a single well-ordered PtdCho molecule occupies a centrally located tunnel
phosphatidylcholine transfer protein gene variants are associated with LDL-peak particle size
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2 (show ACOT13 Proteins)) and the homeodomain transcription factor Pax3 (paired box gene 3 (show PAX3 Proteins)), respectively, as PC-TP-interacting proteins.
These observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets.
Improved glucose tolerance in Pctp(-/-);ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for Phosphatidylcholine transfer protein in diabetes in leptin (show LEP Proteins) deficient mice
Them2 (show ACOT13 Proteins) and phosphatidylcholine transfer protein regulate lipid and glucose metabolism
PC-TP-THEM2 complex reduces phosphorylation and stability of IRS2 and increases stability of the TSC1-TSC2 complex
Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT (show BAAT Proteins).
regulation of cholesterol homeostasis is a physiological function of PC-TP in liver, which can be overcome with a cholesterol-rich lithogenic diet
In Pctp(-/-) mice, there was an accumulation of small alpha-migrating HDL (show HSD11B1 Proteins) particles. PC-TP participates in HDL (show HSD11B1 Proteins) reverse cholesterol transport.
PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations
NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains.
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
START domain-containing protein 2
, StAR-related lipid transfer (START) domain containing 2
, stAR-related lipid transfer protein 2