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PITPNA encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. Additionally we are shipping PITPNA Antibodies (56) and and many more products for this protein.
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Data show that phosphatidylinositol transfer protein alpha (PITPalpha) is involved in the function of mixed lineage kinase domain-like protein (MLKL) in necroptosis.
the PITPalpha structure has to relax to allow access to the Ser166 site, and this may occur at the membrane surface where PI delivery is required for receptor-mediated PLC (show HSPG2 Proteins) signaling
Data suggest that phosphatidylinositol transfer protein (PITP) beta (show PITPNB Proteins) is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals.
PITP alpha has a role with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes
The PITPalpha function in murine cells has no deleterious consequences for growth and bulk phospholipid metabolism.
These results identify a crucial role for PlTPalpha in netrin-1 (show NTN1 Proteins)-induced neurite outgrowth, revealing a signalling mechanism for DCC (show DCC Proteins)/neogenin (show NEO1 Proteins) and PlTPalpha regulation.
This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.
phosphatidylinositol transfer protein, alpha
, phosphatidylinositol transfer protein alpha isoform
, ptdIns transfer protein alpha
, ptdInsTP alpha
, PI-TP 35 kda isoform
, phosphatidylinositol-transfer protein 35 kDa isoform
, Pitp alpha
, PtdIns transfer protein alpha