Phosphogluconate Dehydrogenase Proteins (PGD)

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Additionally we are shipping PGD Antibodies (91) and PGD Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PGD 5226 P52209
PGD 110208 Q9DCD0
PGD 100360180 P85968;
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Top PGD Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human GST tag Phosphogluconate Dehydrogenase (PGD) (AA 4-483), (partial) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
Details
Human Cells Human His tag   50 μg Log in to see 4 Days
$203.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 14 to 16 Days
$327.80
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 13 to 16 Days
$492.31
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Human Cells Human His tag   10 μg Log in to see 15 to 16 Days
$137.50
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,641.83
Details
Yeast Fruit Fly His tag   1 mg Log in to see 60 to 71 Days
$3,358.67
Details

PGD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Phosphogluconate Dehydrogenase (PGD) Interaction Partners

Human Phosphogluconate Dehydrogenase (PGD) interaction partners

  1. identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of anaplastic thyroid cancer (ATC) resistance to doxorubicin. 6PGD inhibition disrupts metabolic reprogramming in doxorubicin-resistant ATC cells.

  2. Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1-AMPK signalling.

  3. copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues

  4. Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.

  5. Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation.

  6. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

  7. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  8. Data suggest that the affinity of Nox2 for NADPH is increased in the presence of 6PGDH on cell stimulation.

  9. Hsa-miR-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.

Mouse (Murine) Phosphogluconate Dehydrogenase (PGD) interaction partners

  1. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

  2. Taken together, these data suggest that ADD1/SREBP1c is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.

PGD Protein Profile

Protein Summary

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.

Gene names and symbols associated with PGD

  • phosphogluconate dehydrogenase (PGD)
  • Phosphogluconate dehydrogenase (Pgd)
  • phosphogluconate dehydrogenase (Pgd)
  • phosphogluconate dehydrogenase L homeolog (pgd.L)
  • phosphogluconate dehydrogenase (pgd)
  • 6-phosphogluconate dehydrogenase, decarboxylating (GND1a|GND1b)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Thal_1580)
  • 6-phosphogluconate dehydrogenase, decarboxylating (GY4MC1_3101)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Odosp_2189)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Marky_1024)
  • 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
  • 6-phosphogluconate dehydrogenase, decarboxylating-like (LOC101451876)
  • 6-pgd protein
  • 6-PGDH protein
  • 6Pgd protein
  • 6pgdh protein
  • 0610042A05Rik protein
  • A7 protein
  • AU019875 protein
  • C78335 protein
  • Cc2-27 protein
  • CG3724 protein
  • Dmel\\CG3724 protein
  • EG:87B1.4 protein
  • fi03d03 protein
  • GND1b protein
  • l(1)2Dc protein
  • l(1)2De protein
  • l(1)A7 protein
  • l(1)G0385 protein
  • l(1)N1 protein
  • l(1)N3[90] protein
  • l(1)Pgd protein
  • l(1)Pgd-A protein
  • l35 protein
  • N1 protein
  • Pdg protein
  • Pgd protein
  • wu:fi03d03 protein
  • zgc:55585 protein
  • zgc:111848 protein

Protein level used designations for PGD

6-phosphogluconate dehydrogenase, decarboxylating , 6-phosphogluconate , 6-phosphogluconate dehydrogenase , CG3724-PA , CG3724-PB , NADP-6 phosphogluconate dehydrogenase , Pgd-PA , Pgd-PB , dehydrogenase , phosphogluconate dehydrogenase , 6-phosphogluconate dehydrogenase (decarboxylating) , 6-phosphogluconate dehydrogenase, decarboxylating-like

GENE ID SPECIES
5226 Homo sapiens
31185 Drosophila melanogaster
110208 Mus musculus
398848 Xenopus laevis
406762 Danio rerio
419450 Gallus gallus
443541 Ovis aries
514939 Bos taurus
5722476 Chlamydomonas reinhardtii
8815110 Thermocrinis albus DSM 14484
9929981 Geobacillus sp. Y4.1MC1
10253936 Odoribacter splanchnicus DSM 220712
10433922 Marinithermus hydrothermalis DSM 14884
10448388 Chlamydophila pecorum E58
100534626 Taeniopygia guttata
100598383 Nomascus leucogenys
397546 Sus scrofa
101451876 Ceratitis capitata
100360180 Rattus norvegicus
101788565 Cavia porcellus
101866917 Macaca fascicularis
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