Phosphomevalonate Kinase Proteins (PMVK)

PMVK encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway.

list all proteins Gene Name GeneID UniProt
Human PMVK PMVK 10654 Q15126
Mouse PMVK PMVK 68603 Q9D1G2
Rat PMVK PMVK 310645  
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Top Phosphomevalonate Kinase Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 8 to 11 Days
$504.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,267.83
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,460.33
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,046.15
Details

More Proteins for Phosphomevalonate Kinase (PMVK) Interaction Partners

Human Phosphomevalonate Kinase (PMVK) interaction partners

  1. Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK).

  2. found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained.

  3. Functional evaluation of conserved basic residues in PMVK is reported.

  4. This is the first report of hPMK crystal structure that suggests a potential substrate binding site and a possible enzyme catalytic mechanism.

  5. Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec).

Phosphomevalonate Kinase (PMVK) Protein Profile

Protein Summary

This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.

Gene names and symbols associated with PMVK

  • phosphomevalonate kinase (PMVK)
  • phosphomevalonate kinase (Mpk)
  • GHMP kinase family protein (AT1G31910)
  • phosphomevalonate kinase (CpipJ_CPIJ015413)
  • phosphomevalonate kinase (Bm1_05275)
  • phosphomevalonate kinase (pmvk)
  • phosphomevalonate kinase (LOAG_11811)
  • phosphomevalonate kinase (Tsp_06629)
  • phosphomevalonate kinase (LOC100282968)
  • phosphomevalonate kinase (Pmvk)
  • 1110011E12Rik protein
  • 2900002L22Rik protein
  • AV001327 protein
  • F5M6.9 protein
  • F5M6_9 protein
  • HUMPMKI protein
  • MPK_Bm protein
  • PMK protein
  • PMKA protein
  • PMKASE protein
  • zgc:162701 protein

Protein level used designations for PMVK

phosphomevalonate kinase , hPMK , PMKase

GENE ID SPECIES
457350 Pan troglodytes
612251 Canis lupus familiaris
692835 Bombyx mori
717014 Macaca mulatta
840081 Arabidopsis thaliana
6049213 Culex quinquefasciatus
6095986 Brugia malayi
8570979 Lactobacillus johnsonii FI9785
9949270 Loa loa
10909538 Trichinella spiralis
100003383 Danio rerio
100282968 Zea mays
10654 Homo sapiens
68603 Mus musculus
310645 Rattus norvegicus
100152301 Sus scrofa
513533 Bos taurus
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