Pinin, Desmosome Associated Protein Proteins (PNN)

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Additionally we are shipping PNN Antibodies (78) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNN 5411 Q9H307
Rat PNN PNN 368070  
PNN 18949 O35691
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Top PNN Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details

PNN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Pinin, Desmosome Associated Protein (PNN) Interaction Partners

Human Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency.

  2. Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation

  3. Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer

  4. Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.

  5. These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.

  6. PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  7. ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.

  8. Urinary desmosine level is an important biologoical marker, in patients treated with bilateral knee replacement and hydrocortison therapy.

  9. Pinin functions as a splicing regulator which participates itself directly in splicing reaction or indirectly via other components of splicing machinery

  10. Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export

  11. the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1

  12. Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression

  13. Corepressor CtBP and PNN/DRS differentially modulate transcription and splicing of the E-cadherin gene.

Zebrafish Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. pnn is essential for the maintenance of subsets of neural crest cells, and that in zebrafish proper cranial neural crest proliferation and differentiation are dependent on pnn expression.

Mouse (Murine) Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  2. Pnn downregulation in skeletal muscle causes a muscular dystrophic phenotype associated with NEB deficiency and the CCD domain is incapable of replacing full length Pnn in terms of functional capacity.

  3. Loss of Pnn induces apoptotic morphology in embryonic stem cells.

  4. The results suggest that astrocytes are unique among cell types of neuroblast origin in terms of expression Pinin protein.

  5. Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis

  6. Spatial and temporal expression profile of pinin during mouse development.

  7. demonstrate abnormal activities of Tcf/Lef transcription factors, and alterations in beta-catenin level in multiple Pnn hypomorphic tissues

PNN Protein Profile

Protein Summary

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).

Gene names and symbols associated with PNN

  • pinin, desmosome associated protein (PNN)
  • pinin, desmosome associated protein (Pnn)
  • pinin, desmosome associated protein (pnn)
  • pinin (Pnn)
  • Pinin (Pnn)
  • pinin (LOC100380709)
  • AU045199 protein
  • CG8383 protein
  • D12Ertd512e protein
  • Dmel\\CG8383 protein
  • dPnn protein
  • DRS protein
  • DRSP protein
  • memA protein
  • MGC88923 protein
  • PNN protein
  • SDK3 protein
  • wu:fb24d03 protein

Protein level used designations for PNN

140 kDa nuclear and cell adhesion-related phosphoprotein , SR-like protein , desmosome-associated protein , domain-rich serine protein , melanoma metastasis clone A protein , neutrophil protein , nuclear protein SDK3 , pinin , fb24d03 , pinin, desmosome associated protein , CG8383-PA , CG8383-PB , Pnn-PA , Pnn-PB , PININ protein

GENE ID SPECIES
5411 Homo sapiens
368070 Rattus norvegicus
403907 Canis lupus familiaris
407733 Danio rerio
423338 Gallus gallus
448224 Xenopus (Silurana) tropicalis
452875 Pan troglodytes
100227753 Taeniopygia guttata
100443066 Pongo abelii
100606214 Nomascus leucogenys
18949 Mus musculus
41185 Drosophila melanogaster
100380709 Salmo salar
100526149 Sus scrofa
100296970 Bos taurus
100060952 Equus caballus
100714770 Cavia porcellus
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