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Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Additionally we are shipping PNN Antibodies (74) and and many more products for this protein.
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Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency.
Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation
Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer
Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.
PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.
ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.
Urinary desmosine level is an important biologoical marker, in patients treated with bilateral knee replacement and hydrocortison therapy.
Pinin functions as a splicing regulator which participates itself directly in splicing reaction or indirectly via other components of splicing machinery
Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export
the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1
Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression
Corepressor CtBP and PNN/DRS differentially modulate transcription and splicing of the E-cadherin gene.
pnn is essential for the maintenance of subsets of neural crest cells, and that in zebrafish proper cranial neural crest proliferation and differentiation are dependent on pnn expression.
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).
140 kDa nuclear and cell adhesion-related phosphoprotein
, SR-like protein
, desmosome-associated protein
, domain-rich serine protein
, melanoma metastasis clone A protein
, neutrophil protein
, nuclear protein SDK3
, pinin, desmosome associated protein
, PININ protein