anti-Pituitary Homeobox 3 (PITX3) Antibodies

Human Pituitary Homeobox 3 (PITX3) interaction partners

1. Results show that a common polymorphism in the PITX3 gene affects the risk of developing Parkinson's disease (PD) dementia and visuospatial dysfunction in idiopathic PD. If validated, these findings can provide new insights into the neurobiology and genetics of non-motor symptoms in PD.

2. Study showed that PITX3 methylation was significantly methylated in head and neck squamous cell carcinoma (HNSCC) tumor compared to normal adjacent tissue and correlated with lymph node status. These results provide evidence that PITX3 DNA methylation (show HELLS Antibodies) is an independent prognostic biomarker for overall survival in patients with HNSCC and might aid in the process of risk stratification for individualized treatment.

3. Study showed that PITX3 and PITX2 (show PITX2 Antibodies) were hypermethylated in prostate carcinomas (PCa (show FLVCR1 Antibodies)) and significantly associated with established clinicopathologic parameters characteristic of PCa (show FLVCR1 Antibodies).

4. These findings suggest that p.A203fs in PITX3 is the cause of cataracts in the recruited family.

5. PITX3 variants rs3758549 and rs4919621 are not associated with ET in Chinese Han population.

6. novel PITX3 mutation c.573del, p.(Ser192Alafs*117), was identified in heterozygous state in a Belgo-Romanian family with a similar phenotype

7. our data demonstrate that key midbrain dopamine regulators (Nurr1 (show NR4A2 Antibodies), Pitx3, and Lmx1a (show LMX1A Antibodies)) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons

8. Mutations in PITX3 are not a common cause or a risk factor for multisystem atrophy and progressive supranuclear palsy in the Polish population.

9. Presence of the rs4919621 allele A in PITX3 significantly increases the risk of Parkinson's disease (PD) patients in a Caucasian population, while rs2281983 allele C and rs4919621 allele A were both risk factors in early onset PD.

10. This study provided that NURR1 (show NR4A2 Antibodies) and PITX3 gene expression is decreased in the peripheral blood lymphocytes of Chinese patients with Parkinson's disease patients.

Xenopus laevis Pituitary Homeobox 3 (PITX3) interaction partners

1. In Xenopus, pitx3 appears to inhibit the rotation of presomitic cell cohorts and to be necessary to the bilaterally symmetric expression of pitx2 (show PITX2 Antibodies) in somites.

2. Microarray-based identification of Pitx3 targets during Xenopus embryogenesis.

3. expression of Pitx3 in the presumptive lens ectoderm is critical for retina development

Mouse (Murine) Pituitary Homeobox 3 (PITX3) interaction partners

1. that Pitx3 is co-recruited to regions that foster the formation of GATA-bHLH-BRN complexes, which usually involve Lmo co-regulatory proteins

2. in absence of En1 (show EN1 Antibodies) and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.

3. Pitx3 is specifically required for DA-related function and, if impaired, Pitx3 could contribute during the pathogenesis of Parkinson's disease.

4. the sonic hedgehog (show SHH Antibodies) signaling pathway is both necessary and sufficient for the induction of ectopic PITX3 expression in chick mesencephalon downstream of WNT9A (show WNT9A Antibodies)-induced LMX1a (show LMX1A Antibodies) transcription.

5. microphthalmos/aphakia inPITX3 nonsense mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins.

6. Pitx3 binds to an evolutionary conserved bicoid-binding site on the 5'-upstream region of Foxe3 (show FOXE3 Antibodies). Pitx3 binding to 5'-upstream region of Foxe3 (show FOXE3 Antibodies) increased transcriptional activity significantly in a cell-based reporter assay.

7. During fetal myogenesis, Pitx2 (show PITX2 Antibodies)/3 control this redox state through the regulation of Nrf1 (show NRF1 Antibodies) and of antioxidant pathways.

8. Pitx3 overexpressing mouse significantly affects the gene expression of midbrain dopamine neurons. Motor coordination and locomotion activities are significantly affected in mice overexpressing Pitx3 mice.

9. Primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage.

10. Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 (show EN1 Antibodies) and Pitx3, interact in dopaminergic subset specification.

Zebrafish Pituitary Homeobox 3 (PITX3) interaction partners

1. pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog (show SHH Antibodies) and nodal proteins' signaling.

2. results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish

3. Data demonstrate that Foxe3 (show FOXE3 Antibodies) is necessary for lens development in zebrafish and that foxe3 (show FOXE3 Antibodies) lies genetically downstream of pitx3 in a zebrafish lens development pathway.

4. while lmx1b (show LMX1B Antibodies) paralogues may contribute to the generation of diencephalic dopaminergic precursors. Conversely, knock-down of pitx3 does not specifically affect any diencephalic dopamine cluster