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PF4 encodes a member of the CXC chemokine family. Additionally we are shipping Platelet Factor 4 Kits (107) and Platelet Factor 4 Proteins (68) and many more products for this protein.
Showing 10 out of 169 products:
Human Monoclonal PF4 Primary Antibody for CyTOF, FACS - ABIN4900200
Dubrac, Quemener, Lacazette, Lopez, Zanibellato, Wu, Bikfalvi, Prats: Functional divergence between 2 chemokines is conferred by single amino acid change. in Blood 2010
Show all 2 Pubmed References
Human Polyclonal PF4 Primary Antibody for ELISA, IHC (p) - ABIN4265396
Zhang, Mercado-Uribe, Liu: Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel. in International journal of cancer 2013
Human Monoclonal PF4 Primary Antibody for FACS - ABIN4897342
van Bon, Affandi, Broen, Christmann, Marijnissen, Stawski, Farina, Stifano, Mathes, Cossu, York, Collins, Wenink, Huijbens, Hesselstrand, Saxne, DiMarzio, Wuttge, Agarwal, Reveille, Assassi, Mayes et al.: Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. ... in The New England journal of medicine 2014
PF4 was produced by Ly6G+CD11b (show ITGAM Antibodies)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.
The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (show CXCR3 Antibodies) N-Terminal Sulfated (show SULF1 Antibodies) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.
data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation
Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.
Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
These data demonstrate that the CXCR2 (show CXCR2 Antibodies) network and CXCL4 play a role in the maintenance of normal HSC (show FUT1 Antibodies)/HPC cell fates, including survival and self-renewal.
The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC (show FUT1 Antibodies) quiescence as well as BM niche cells.
binding of PF4 to perlecan (show HSPG2 Antibodies) was found to inhibit both FGF2 (show FGF2 Antibodies) signaling and platelet activation
CXCL4 plays an important role in pancreatic inflammation
Platelet-derived CXCL7 (show PPBP Antibodies) and CXCL4 contribute to the pathogenesis of acute lung injury.
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.
CXCL4 regulates hematopoietic stem cell cell cycle activity.
Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4