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p53/TP53-regulated repressor of Akt/AKT1 signaling. Additionally we are shipping PHLDA3 Antibodies (32) and PHLDA3 Kits (1) and many more products for this protein.
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Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt (show AKT1 Proteins) activation may be a therapeutic target in ESCCs
Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).
findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression
Study identifies PHLDA3 as a p53 (show TP53 Proteins) target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt (show AKT1 Proteins) for binding of membrane lipids, inhibiting Akt (show AKT1 Proteins) translocation to the cellular membrane and activation.
Phlda3 may cause p53 (show TP53 Proteins) accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.
Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.
Ipl (show PHLDA2 Proteins) and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 Proteins).
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).
pleckstrin homology-like domain, family A, member 3
, TDAG51/Ipl homolog 1
, pleckstrin homology-like domain family A member 3
, pleckstrin homology-like domain, family A, member 2
, TDAG/lpl homolog 1