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PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities.
Showing 10 out of 91 products:
Human Monoclonal PLAGL1 Primary Antibody for ELISA, WB - ABIN1724868
Liu, Hsieh, Liu, Chang, Lin, Wang, Huang: Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells. in Experimental cell research 2011
report here a novel PLAGL1 promoter (P5) derived from the insertion of a primate-specific, MIR3 SINE retrotransposon. P5 is highly utilized in lymphocytes, particularly in T cells, and like P2, directs biallelic transcription
Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition.
PLAGL1 methylation/expression may be altered after assisted reproductive technologies.
These results suggest that OCT (show Plxna2 Antibodies) attenuates SGC (show SGCB Antibodies)-7901 cell proliferation by enhancing P300-HAT (show EP300 Antibodies) activity through the interaction of ZAC and P300 (show EP300 Antibodies), causing a reduction in pS10-H3 and an increase in acK14-H3. These findings provide insight for future research on OCT (show Plxna2 Antibodies) and further demonstrate the potential of OCT (show Plxna2 Antibodies) to be used as a therapeutic agent for gastric cancer
High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma (show MOK Antibodies).
Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC (show CALR Antibodies)) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC (show CALR Antibodies).
Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta.
DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma
There is positive correlations between the ZAC1 DMR (show WDR20 Antibodies) methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03).
ZAC1 and SSTR2 (show SSTR2 Antibodies) are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas.
PLAGL1 is maternally imprinted in swine. Expression profiling using short-oligonucleotide microarrays of parthenotes and control fetal tissues supports imprinted isoform-specific expression.
The expression patterns of PLAGL1 and PEG10 (show PEG10 Antibodies) genes in two breeds of swine are reported.
Zac1/GPR39 (show GPR39 Antibodies) system promotes the formation of type II muscle fibers by phosphorylation of CaMK-II (show CAMK2B Antibodies). Cells lacking Zac1/GPR39 (show GPR39 Antibodies) system tend to remain stemness and form type I muscle fibers after induced differentiation.
expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.
Transcription factor MEF2 (show MEF2C Antibodies) and Zac1 mediate MIF (show MIF Antibodies)-induced GLUT4 (show SLC2A4 Antibodies) expression through CD74 (show CD74 Antibodies)-dependent AMPK (show PRKAA1 Antibodies) activation in cardiomyocytes
we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development
Zac1 interacts with two cis (show CISH Antibodies)-regulatory elements in the Tcf4 (show TCF4 Antibodies) gene locus.
results indicate ZAC is a negative regulator of the acute stimulatory effects of glucose on beta-cells. It provides an explanation for both insulin (show INS Antibodies) deficiency in the neonate and the later relapse of diabetes in patients with transient neonatal diabetes mellitus cases
Hymai and Plagl1it RNAs both have potentially high affinity for Trithorax (show MLLT1 Antibodies) chromatin regulators.
identified the guanine nucleotide exchange factor Rasgrf1 (show RASGRF1 Antibodies) as a direct Zac1/Plagl1 target gene in beta cells
Zac1 inhibits nuclear factor Kappa B activity by interacting with the C-terminus of the p65 (show NFkBP65 Antibodies) subunit, which suppresses the phosphorylation of p65 (show NFkBP65 Antibodies) at Ser468 and Ser536 residues
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.
pleiomorphic adenoma gene-like 1
, zinc finger protein PLAGL1-like
, PLAG-like 1
, lost on transformation 1
, pleiomorphic adenoma-like protein 1
, tumor suppressor ZAC
, tumor supressor ZAC
, zinc finger protein PLAGL1
, zinc finger protein Zac 1
, zinc finger protein regulator of apoptosis and cell cycle arrest
, Lost on transformation 1