Plexin B1 Proteins (PLXNB1)

Mouse (Murine) Plexin B1 (PLXNB1) interaction partners

1. These results demonstrate a novel physiological function for sema4D/plxnB1 signaling in retinal pigment epithelium phagocytosis.

2. Plexin-B1 coordinates cell repolarization through RhoA-ROCK-mediated redistribution of Plexin-B1.

3. Plexin-B1 and -B2 play redundant or compensatory roles during forebrain development to ensure proper neuronal production and neocortical expansion.

4. Deletion of plexin-B1, the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.

5. Sema 4D/CD100 is not only a ligand for plexin B1 but also a direct signaling receptor in mediating Sema 4D/CD100-plexin B's biological functions.

6. In ErbB-2-overexpressing murine breast cancer, ablation of Plexin-B1 genes strongly reduced metastases. Plexin-B1 has no effect on tumorigenesis or tumor growth but is required for metastasis of ErbB-2-dependent breast cancers in vivo.

7. Semaphorin 4D-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production are mediated through plexin-B1.

8. a lack of plexin-B1 did not impact on cortical development in vivo

9. LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization.

10. binding of Sema 4D to Plexin B1 stimulates the tyrosine kinase activity of Met

11. Results suggest that plexin-A1 and B1 interact in the adult brain and transduce semaphorin 3A signaling in cooperation.

12. Plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension.

13. The mechanism of semaphorin D in the activation of the MAPK pathway via plexin-B1 is reported.

14. A possible role for plexin-B1 in ovarian follicle growth and steroidogenesis, most likely via the granulosa cells, is suggested.

15. In the ovarian follicle, the effect of Plexin-B1 is mediated by semaphorin-4D.

16. PlexinB1 plays a redundant role in mouse development and it is not strictly required for tumour induced angiogenesis

17. A loss of plexin-B1 expression in mice does not significantly impact the development of the nervous system.

18. A functional role for CD100 antigen/Plxnb1 interactions in epithelial branching morphogenesis during organogenesis is reported.

19. B-Raf/MKK/ERK provides a permissive environment for melanoma genesis by modulating plexin B1.

Human Plexin B1 (PLXNB1) interaction partners

1. Decreased expression of sema4D and Plexin-B1 may be responsible for the deficiency in Met signalling and the development of preeclampsia.

2. Plexin-B1 level showed a significant positive correlation both with overall survival and disease free survival of Caucasian breast cancer patients

3. Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.

4. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival in colorectal cancer.

5. Loss of plexin B1 expression might play a pivotal role in enhancing the metastatic potential of breast cancer cells.

6. Plexin B1 expression was regulated by TMPRSS2-ERG fusion gene in prostate cancer.

7. Plexin-B1 mediates RhoA/integrin alphavbeta3 involved in the PI3K/Akt pathway and SRPK1 to influence the growth of glioma cell, angiogenesis, and motility in vitro and in vivo.

8. results show that Sema4D/plexin-B1 signaling promotes the translocation of androgen receptor to the nucleus and thereby enhances AR transcriptional activity

9. Plexin-B1 induces cutaneous squamous cell carcinoma cell proliferation, migration, and invasion by interacting with Sema4D. Plexin-B1 might serve as a useful biomarker and/or as a novel therapeutic target for cSCC.

10. Results show that decreased expression of Sema4D, plexin-B1 and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.

11. Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis

12. Blocking of CD100, plexin B1 and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.

13. The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4.

14. Activation of endogenous plexin-B1 enhances cell migration and tumor invasiveness in prostate cancer cells.

15. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa.

16. ErbB-2 overexpression in human breast & ovarian cancer cell lines leads to phosphorylation & activation of Plexin-B1. This was required for ErbB-2-dependent activation of RhoA & RhoC & promoted invasive behavior.

17. PlexinB1 mutations block plexinB1-mediated signalling pathways that inhibit cell motility.

18. evidence that Sema4D/Plexin-B1-mediated NF-kappaB activation and IL-8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells

19. Two crystal structures of the human Plexin-B1 cytoplasmic region in complex with a constitutively active RhoGTPase, Rac1, are reported.

20. The binding of Sema4D to plexinB1 induced small GTPase Ras homolog gene family, member A activation and resulted in the phosphorylation of MAPK and Akt.