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The protein encoded by PAIP1 interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. Additionally we are shipping Poly(A) Binding Protein Interacting Protein 1 Proteins (6) and many more products for this protein.
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Cow (Bovine) Polyclonal PAIP1 Primary Antibody for WB - ABIN2778987
Fortna, Kim, MacLaren, Marshall, Hahn, Meltesen, Brenton, Hink, Burgers, Hernandez-Boussard, Karimpour-Fard, Glueck, McGavran, Berry, Pollack, Sikela: Lineage-specific gene duplication and loss in human and great ape evolution. in PLoS biology 2004
Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 (show WWP2 Antibodies) as a suppressor of translation.
The Paip1-eIF3 (show EIF3A Antibodies) interaction is impaired by the mTORC1 inhibitors.
the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported.
Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP (show PABPC1 Antibodies) & initiation factors eIF4A (show EIF4A1 Antibodies) & eIF3 (show EIF3A Antibodies). Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A.
Paip1 interacts with poly(A) binding protein through two independent binding motifs.
eIF3 (show EIF3A Antibodies)-Paip1 stabilizes the interaction between PABP (show PABPC1 Antibodies) and eIF4G (show EIF4G1 Antibodies), which brings about the circularization of the mRNA.
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
PABC1-interacting protein 1
, PABP-interacting protein 1
, poly(A)-binding protein-interacting protein 1
, polyadenylate binding protein-interacting protein 1
, polyadenylate-binding protein-interacting protein 1
, poly(A) binding protein interacting protein 1
, polyadenylate-binding protein-interacting protein 1-like