Polymerase (DNA Directed), gamma Proteins (POLG)

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Additionally we are shipping POLG Antibodies (57) and POLG Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POLG 5428 P54098
POLG 18975  
Rat POLG POLG 85472 Q9QYV8
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top POLG Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Escherichia coli (E. coli) REACT_Human rhinovirus A His-SUMO Tag   50 μg Log in to see 11 Days
Escherichia coli (E. coli) Hepatitis C Virus His-SUMO Tag   50 μg Log in to see 11 Days
Yeast REACT_Human rhinovirus 1A His tag   50 μg Log in to see 8 to 11 Days
Yeast REACT_Human rhinovirus A His tag   50 μg Log in to see 8 to 11 Days
Yeast Hepatitis C Virus His tag   50 μg Log in to see 8 to 11 Days
Yeast Dengue virus type 2 His tag   50 μg Log in to see 8 to 11 Days
Mammalian Cells REACT_Hepatitis A Virus His tag   100 μg Log in to see 2 to 3 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

POLG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Polymerase (DNA Directed), gamma (POLG) Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The stimulatory effect of mtSSB (show SSBP1 Proteins) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific (show EIF3K Proteins) overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (show SSBP1 Proteins) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (show RPA1 Proteins) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation.

  2. One patient presented with Leigh syndrome and had a homozygous deletion in the NDUFAF2 gene, while the second patient had a homozygous mutation in the POLG gene, [c.1399G>A; p.Ala467Thr].

  3. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  4. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  5. POLG mutations are associated with progressive external ophthalmoplegia.

  6. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

  7. This review presented that the patient with epilepsy due to homozygous pathogenic variants located in the linker region of POLG were associated with later age of onset and longer survival compared to compound heterozygous variants.

  8. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication.

  9. Study further demonstrated the broad POLG-related spectrum and led to the identification of Sensory Ataxic Neuropathy with Ophthalmoparesis but without dysarthria (SANO), a new yet common phenotype of this spectrum characterized by the lack of cerebellar signs and by a less severe prognosis than in Sensory Ataxic Neuropathy, Dysarthria and Ophthalmoparesis (SANDO) and Spino (show PPP1R9B Proteins) Cerebellar Ataxia with Epilepsy (SCAE)

  10. molecular dynamics simulations of the human Pol gamma replicative complex

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation (show HELLS Proteins).

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease (show EXOSC10 Proteins) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO and Alpers syndrome, and the exonuclease deficient pol-gamma (exo(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (show EXOSC10 Proteins) activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG Protein Profile

Protein Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • tamas (tam)
  • DNA polymerase gamma, catalytic subunit (POLG)
  • polymerase (DNA directed), gamma (POLG)
  • DNA polymerase gamma 35kD (DNApol-gamma35)
  • polymerase (DNA directed), gamma (polg)
  • polymerase (DNA directed), gamma (Polg)
  • DNA polymerase gamma, catalytic subunit (Polg)
  • polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L)
  • 34Dc protein
  • AA409516 protein
  • AAC47658 protein
  • anon-34Dc protein
  • BG:DS00941.6 protein
  • BG:DS00941.9 protein
  • br5 protein
  • br16 protein
  • cDNA 2 protein
  • CG8969 protein
  • CG8987 protein
  • CG33084 protein
  • CG33650 protein
  • D-pol gamma-alpha protein
  • D-pol gamma-beta protein
  • Dmel\\CG8987 protein
  • Dmel\\CG33650 protein
  • DNA pol-gam.35 protein
  • DNApol-gamma protein
  • DNApol-gamma.35 protein
  • DNApol-gamma125 protein
  • l(2)34Dc protein
  • l(2)34De protein
  • l(2)br5 protein
  • l(2)br14 protein
  • l(2)br16 protein
  • l(2)brS protein
  • MDP1 protein
  • MIRAS protein
  • mtDNA pol protein
  • MTDPS4A protein
  • MTDPS4B protein
  • mtPolA protein
  • MtPolB protein
  • PEO protein
  • PolG protein
  • POLG1 protein
  • PolgA protein
  • polgamma protein
  • pol gamma protein
  • pol gamma-alpha protein
  • polgamma-alpha protein
  • polgamma-beta protein
  • pol gamma-beta protein
  • pol gamma35 protein
  • SANDO protein
  • SCAE protein
  • Tam protein

Protein level used designations for POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
Selected quality suppliers for POLG Proteins (POLG)
Did you look for something else?