anti-Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B) Antibodies

POLR3B encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. Additionally we are shipping Polymerase (RNA) III (DNA Directed) Polypeptide B Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLR3B 362858  
POLR3B 55703 Q9NW08
POLR3B 70428 P59470
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Top anti-Polymerase (RNA) III (DNA Directed) Polypeptide B Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-POLR3B Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human heart 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of POLR3B staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit Western blot analysis of POLR3B expression in Hela (A), HepG2 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of POLR3B using LOVO whole cell lysates ABIN6272397 staining LOVO by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 11 to 14 Days
$493.17
Details
Mouse Rabbit Un-conjugated WB Western blot analysis in mouse spleen tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$550.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μL Available
$359.79
Details
Human Rabbit Un-conjugated WB Western blot (WB) analysis of POLR3B polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate(20ug) Lane2:H9C2 whole cell lysate(20ug) Lane3:U-87MG whole cell lysate(40ug) Lane4:HCT116 whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug) 100 μL 6 to 11 Days
$350.00
Details
Fruit Fly Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$550.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 11 to 16 Days
$309.53
Details

Top referenced anti-Polymerase (RNA) III (DNA Directed) Polypeptide B Antibodies

  1. Cow (Bovine) Polyclonal POLR3B Primary Antibody for WB - ABIN2783516 : Yee, Gong, Huang, Lorent, Dolan, Maraia, Pack: Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. in PLoS biology 2007 (PubMed)

  2. Human Monoclonal POLR3B Primary Antibody for ELISA, WB - ABIN527631 : Shen, Lei, Liu, Zheng, Song, Marc, Wang, Sun, Liang: Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression. in Experimental cell research 2009 (PubMed)

More Antibodies against Polymerase (RNA) III (DNA Directed) Polypeptide B Interaction Partners

Human Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B) interaction partners

  1. Three novel mutations of POLR3B c.727A>G (p.Met243Val) and c.2669G>A (p.Arg890His) (P1, P2), and c.1495G>A (p.Met499Val) (P3) were found

  2. Novel compound heterozygous variations in POLR3B were identified in a patient with cerebellar hypoplasia with endosteal sclerosis.

  3. The spectrum of phenotypes resulting from POLR3B mutations is wider than previously believed.

  4. Findings suggest that AP-1 factors are regulators of RNA polymerase III (Pol III)-driven 5S rRNA and U6 snRNA expression with a potential role in cell proliferation.

  5. Multicenter retrospective study to collect neuroradiologic, clinical, and molecular data of patients with mutations in POLR3A and POLR3B without the classic MRI phenotype: diffuse hypomyelination is not an obligatory feature of POLR3-related disorders; two distinct patterns, selective involvement of the corticospinal tracts and cerebellar atrophy, are added to the MRI presentation of POLR3-related disorders

  6. first reports of long deletions causing POLR3-related leukodystrophy, suggesting that deletions and duplications in POLR3A or POLR3B should be investigated in patients with a compatible phenotype

  7. Mutations in POLR3A or POLR3B are rare in patients with unclassified hypomyelination.

  8. INMAP as a model regulator of CENP-B

  9. These results suggest that INMAP might function through p53/p21 pathways.

  10. Most patients with 4H leukodystrophy carried the common c.1568T>A POLR3B mutation on one allele.

  11. MRI in patients with POLR3B mutations revealed smaller cerebellar structures, especially vermis, than those in POLR3A mutations. MRI also showed milder hypomyelination in patients with POLR3B mutations than those with POLR3A mutations

  12. Investigated POLR3A and POLR3B mutations in patients with genetically unexplained hypomyelinating leukodystrophies with features of Pol III-related leukodystrophies. Recessive mutations in POLR3A or POLR3B were uncovered in all 14 patients.

  13. study reports INMAP is a truncated version of POLR3B, and is up-regulated in several human cancer cell lines; results suggest that INMAP may function through the p53 and AP-1 pathways, providing a possible link of its activity with tumourigenesis

  14. Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy

  15. Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy

  16. Results suggest that INMAP is a novel protein that plays essential role in spindle formation and cell-cycle progression.

  17. Data describe the purification and identification of RNA polymerase III subunits RPC2 and RPC5.

Mouse (Murine) Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B) interaction partners

  1. The Polr3b in the hippocampus in the prefrontal cortex of the DBA/2 J strain were up-regulated.

Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B) Antigen Profile

Protein Summary

This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with POLR3B

  • RNA polymerase III subunit B (Polr3b) antibody
  • RNA polymerase III subunit B (POLR3B) antibody
  • polymerase (RNA) III (DNA directed) polypeptide B (Polr3b) antibody
  • 2700078H01Rik antibody
  • A330032P03Rik antibody
  • C128 antibody
  • C85372 antibody
  • HLD8 antibody
  • RGD1565311 antibody
  • RPC2 antibody

Protein level used designations for POLR3B

DNA-directed RNA polymerase III subunit RPC2 , DNA-directed RNA polymerase III 127.6 kDa polypeptide , DNA-directed RNA polymerase III subunit B , RNA polymerase III subunit C2 , C128 , DNA-directed RNA polymerase III B , RNA polymerase III subunit RPC2 homolog

GENE ID SPECIES
362858 Rattus norvegicus
418071 Gallus gallus
474531 Canis lupus familiaris
55703 Homo sapiens
70428 Mus musculus
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