anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) Antibodies

PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA processing and degradation (Raijmakers et al., 2002. Additionally we are shipping Polyribonucleotide Nucleotidyltransferase 1 Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPT1 87178 Q8TCS8
PNPT1 71701 Q8K1R3
PNPT1 360992  
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Top anti-Polyribonucleotide Nucleotidyltransferase 1 Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with PNPT1 antibody ABIN462230 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Skin (formalin-fixed, paraffin-embedded) stained with PNPT1 antibody ABIN462230 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of PNPT1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PNPT1 expression in Jurkat (A), MCF7 (B), HeLa (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PNPT1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of PNPT1 transfected lysate using anti-PNPT1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with PNPT1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of PNPT1 expression in transfected 293T cell line by PNPT1 MaxPab polyclonal antibody.Lane 1: PNPT1 transfected lysate(85.90 KDa).Lane 2: Non-transfected lysate. 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) 100 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PNPase using HeLa whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western Blot analysis of PNPT1 expression in transfected 293T cell line by PNPT1 MaxPab polyclonal antibody.Lane 1: PNPT1 transfected lysate(85.90 KDa).Lane 2: Non-transfected lysate. PNPT1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PNPT1 expression in human kidney. 100 μg 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of PNPT1 expression in transfected 293T cell line by PNPT1 MaxPab polyclonal antibody.Lane 1: PNPT1 transfected lysate(86.13 KDa).Lane 2: Non-transfected lysate. PNPT1 MaxPab polyclonal antibody. Western Blot analysis of PNPT1 expression in rat brain. 50 μg 11 to 12 Days
$440.00
Details

More Antibodies against Polyribonucleotide Nucleotidyltransferase 1 Interaction Partners

Human Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) interaction partners

  1. PNPT1-related disorders may constitute a spectrum rather than distinct phenotypes.

  2. Our cases expand the phenotypic spectrum of PNPT1 mutations that can cause delayed myelination.

  3. The disease-linked human PNPase mutants, Q387R and E475G, form dimers, not trimers, and have significantly lower RNA binding and degradation activities compared to wild-type. The S1 domain is responsible for binding structured RNAs. The RNA-binding K homology and S1 domains are inaccessible in the dimeric assembly. Mutations at the trimeric PNPase interface produce a dimeric protein with destructsive RNA-binding surfaces.

  4. The PNPT1 p.Arg136His and p.Pro140Leu variants in our subject showed 1) the mutated amino acids are highly conserved and our structural analysis supported them to be functionally deleterious; 2) The carrier frequencies of the variants are very low in populations (1:60.000), with no homozygous carriers found; 3) The RC complex amounts in the subject's myoblasts were functionally rescued by expression of wild-type PNPT1.

  5. Inhibition of homologous PNPase by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism.

  6. In vitro rescue experiments, using exogenous expression of wild-type PNPT1 in patient fibroblasts, ameliorated the deficiencies in the OXPHOS complex protein expression, supporting the likely pathogenicity of these variants and the importance of Whole-exome sequencingin efficiently identifying rare genetic disease genes

  7. this study provides further evidence that hPNPase(old-35) is associated with global changes in cell cycle-associated genes and identifies potential gene targets for future investigation

  8. fresh insight into cellular pathways regulated by PNPT1

  9. Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation.

  10. A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.

  11. Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency.

  12. a novel role of nEGFR in radioresistance, and that is, upon ionizing radiation, nEGFR inactivates the ribonuclease activity of PNPase toward c-MYC mRNA through DNAPK-mediated Ser-776 phosphorylation

  13. The study provides structural and functional insights into hPNPase, which uses a KH pore to trap a long RNA 3' tail that is further delivered into an RNase PH channel for the degradation process.

  14. targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions

  15. The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria.

  16. Inhibition of PNPase by shRNA or stable overexpression of miR-221 protected melanoma cells from IFN-beta-mediated growth inhibition, accentuating the importance of PNPase induction and miR-221 down-regulation in mediating IFN-beta action.

  17. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring

  18. an important role for hPNPase(old-35)in growth control associated with terminal differentiation and cellular senescence.

  19. the molecular mechanism of the growth-arresting property of hPNPaseold-35

  20. demonstrate that the hPNPase is localized in mitochondria; finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence

Mouse (Murine) Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) interaction partners

  1. This study establishes PNPase as a contributor to mitochondrial miRNA import through the transport of miRNA-378, which may regulate bioenergetics during type 2 diabetes mellitus.

  2. The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria

Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7.

Gene names and symbols associated with PNPT1

  • polyribonucleotide nucleotidyltransferase 1, mitochondrial (CpipJ_CPIJ005886) antibody
  • polyribonucleotide nucleotidyltransferase 1 (PNPT1) antibody
  • polyribonucleotide nucleotidyltransferase 1 (Pnpt1) antibody
  • 1200003F12Rik antibody
  • COXPD13 antibody
  • DFNB70 antibody
  • old-35 antibody
  • Old35 antibody
  • PNPase antibody
  • Pnptl1 antibody

Protein level used designations for PNPT1

polyribonucleotide nucleotidyltransferase 1, mitochondrial , 3'-5' RNA exonuclease OLD35 , PNPase 1 , PNPase old-35 , polynucleotide phosphorylase 1 , polynucleotide phosphorylase-like protein

GENE ID SPECIES
6037837 Culex quinquefasciatus
87178 Homo sapiens
481376 Canis lupus familiaris
508877 Bos taurus
71701 Mus musculus
360992 Rattus norvegicus
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