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The protein encoded by KCNK10 belongs to the family of potassium channel proteins containing two pore-forming P domains. Additionally we are shipping Potassium Channel, Subfamily K, Member 10 Proteins (3) and many more products for this protein.
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The M2-glycine hinge controls the macroscopic currents of TREK1 (show KCNK2 Antibodies) channels.
This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.
The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position.
Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK (show KCNK4 Antibodies), TREK1 (show KCNK2 Antibodies), and TREK2.
Modulation of K2P 2.1 and K2P 10.1 K(+) channel (show KCNC4 Antibodies) sensitivity to carvedilol by alternative mRNA translation initiation
PLD2 (show PLD2 Antibodies), but not PLD1, directly binds to the C terminus of TREK1 (show KCNK2 Antibodies) and TREK2.
crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK (show KCNK2 Antibodies) channels; results provide an explanation for TREK (show KCNK2 Antibodies) channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac
High TREK-2 expression is associated with epithelial ovarian cancer.
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.
Hyperoxia treatment of TREK-1/TREK (show KCNK2 Antibodies)-2/TRAAK (show KCNK4 Antibodies)-deficient mice is associated with a reduction in surfactant proteins
Formation of TREK-1/TREK (show KCNK2 Antibodies)-2 channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues.
The results suggest that positive modulation of the TREK2 channel may have beneficial analgesic effects in these neuropathic conditions.
Two novel splice isoforms of Trek2 are characterized, both showing prominent expression in the central nervous system and suggesting a potential role for Trek2 amino terminus in channel trafficking and/or stability.
KCNK10 plays an important role in the early stages of preadipocyte differentiation.
TREK (show KCNK2 Antibodies) channels may represent the AMPK (show PRKAA1 Antibodies)-inhibited background K(+) channels that mediate activation of glomus cells by hypoxia.
TREK-2 contributes to the background K+ conductance in MIN6 cells, and may regulate depolarization-induced secretion of insulin (show INS Antibodies)
TREK-1 (show KCNK2 Antibodies), TREK-2, and TRAAK (show KCNK4 Antibodies) are lysophosphatidic acid-operated K+ channels
Identification of the large-conductance background K+ channel (show KCNC4 Antibodies) in mouse B cells as TREK-2.
Data show thatA single conserved residue, H126 in TREK1 (show KCNK2 Antibodies) and H151 in TREK2, is involved in proton sensing.
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
potassium channel, subfamily K, member 10
, 2P domain potassium channel TREK2
, TREK-2 K(+) channel subunit
, TWIK-related K+ channel 2
, outward rectifying potassium channel protein TREK-2
, potassium channel TREK-2
, potassium channel subfamily K member 10
, TREK-2 two-pore-domain K+ channel
, outward rectifying potassium channel TREK2