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The protein encoded by KCNK16 belongs to the family of potassium channel proteins containing two pore-forming P domains. Additionally we are shipping and many more products for this protein.
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data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes.
The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion.
These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion.
at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas.
TALK-1 reduces delta-cell cytosolic Ca2+ elevations and somatostatin release by limiting delta-cell Ca2+-induced Ca2+ release.
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
potassium channel, subfamily K, member 16
, potassium channel subfamily K member 16
, 2P domain potassium channel Talk-1
, TWIK-related alkaline pH-activated K(+) channel 1
, pancreatic potassium channel Talk-1