anti-Potassium Channel Subfamily K Member 1 (KCNK1) Antibodies

KCNK1 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. Additionally we are shipping KCNK1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNK1 16525 O08581
KCNK1 3775 O00180
KCNK1 59324 Q9Z2T2
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Top anti-KCNK1 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNK1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human heart 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNK1 Antibody (C-term) in ZR-75-1 cell line lysates (35ug/lane). This demonstrates the KCNK1 antibody detected the KCNK1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with KCNK1 Antibody (C-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCNK1 Antibody (C-term) in A549 cell line lysates (35ug/lane). This demonstrates the KCNK1 antibody detected the KCNK1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of TWIK1 expression in HeLa (A), A431 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using KCNK1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6275370 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod ABIN6275370 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Horse Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$616.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB   0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
Details

Top referenced anti-KCNK1 Antibodies

  1. Human Polyclonal KCNK1 Primary Antibody for ICC, IF - ABIN4328480 : Zhao, Xiong, Wilber, Cohen, Kreindler: A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells. in American journal of physiology. Lung cellular and molecular physiology 2011 (PubMed)

More Antibodies against KCNK1 Interaction Partners

Mouse (Murine) Potassium Channel Subfamily K Member 1 (KCNK1) interaction partners

  1. results reveal the local conformational changes of the TWIK1 selectivity filter and suggest that the amide-I bands may be useful "molecular fingerprints" for assessing the properties of other K(+) channels

  2. the activation of mGluR3 up-regulates the membrane expression of TWIK-1 that in turn enhances NH4(+) uptake in astrocytes.

  3. KCNK1 was significantly induced during osteoclast differentiation, but its functional overexpression significantly inhibited osteoclast differentiation induced by RANKL

  4. TWIK-1 is functionally expressed in dentate gyrus granule cells and contributes to the intrinsic excitability of these cells.

  5. TWIK-1/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate release from astrocytes.

  6. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability.

  7. Specifically localized in 'non-sensory' cells of inner ear, in dark cells of vestibule and in strial marginal cells of cochlea. May have role in regulation of K(+) homeostasis in dark cells and in strial marginal cells.

  8. A fall in quinidine-sensitive conductance could be an adaptive response in TWIK-1 knockout ducts.

Human Potassium Channel Subfamily K Member 1 (KCNK1) interaction partners

  1. Dynamics of the TWIK-1 Channel

  2. Our data indicate that TWIK-1 has a highly conserved role in cardiac function and is required for normal heart rate and atrial morphology. Despite the functional importance of TWIK-1 in the atrium, genetic variation in KCNK1 is not a common primary cause of human AF.

  3. TWIK-1 protein possesses a hydrophobic barrier deep within the inner pore

  4. Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells

  5. study presents the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1; an extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals

  6. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability.

  7. TWIK1 is internalized via a dynamin-dependent mechanism and addressed to the recycling endosomal compartment. Mutation in its cytoplasmic C terminus (I293A,I294A) stabilizes TWIK1 at the plasma membrane, resulting in robust currents.

  8. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage.

  9. support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes

KCNK1 Antigen Profile

Protein Summary

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.

Gene names and symbols associated with KCNK1

  • potassium channel, subfamily K, member 1 (Kcnk1) antibody
  • potassium two pore domain channel subfamily K member 1 (KCNK1) antibody
  • potassium two pore domain channel subfamily K member 1 (Kcnk1) antibody
  • potassium channel, two pore domain subfamily K, member 1 L homeolog (kcnk1.L) antibody
  • potassium channel, subfamily K, member 1a (kcnk1a) antibody
  • AI788889 antibody
  • DPK antibody
  • HOHO antibody
  • im:7150627 antibody
  • K2P1 antibody
  • k2p1.1 antibody
  • kcnk1 antibody
  • KCNO1 antibody
  • rabKCNK1 antibody
  • Twik antibody
  • twik-1 antibody
  • twik1 antibody
  • zgc:165664 antibody

Protein level used designations for KCNK1

inward rectifying potassium channel protein TWIK-1 , potassium channel subfamily K member 1 , potassium channel KCNO1 , potassium inwardly-rectifying channel, subfamily K, member 1 , putative potassium channel TWIK , rTWIK , potassium channel TWIK-1 , potassium channel, subfamily K, member 1

GENE ID SPECIES
16525 Mus musculus
3775 Homo sapiens
59324 Rattus norvegicus
379125 Xenopus laevis
505563 Bos taurus
100008962 Oryctolagus cuniculus
100135567 Cavia porcellus
793480 Danio rerio
Selected quality suppliers for anti-KCNK1 (KCNK1) Antibodies
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