anti-Potassium Channel Subfamily K Member 18 (KCNK18) Antibodies

mouse homolog induces a time-independent, noninactivating K+ current [RGD, Feb 2006].. Additionally we are shipping KCNK18 Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNK18 338567 Q7Z418
KCNK18 332396 Q6VV64
KCNK18 445371 Q6Q1P3
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Top anti-KCNK18 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-KCNK18 / TRESK antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg 12 to 14 Days
$686.14
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 µg/ml. 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated ELISA, FM, IHC, WB Immunofluorescence of TRESK Antibody Immunofluorescence Microscopy of TRESK antibody. Tissue: Rat brain cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: TRESK antibody at 20 µg/mL for 1 h at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: TRESK is nuclear and cytoplasmic. Staining: TRESK as red fluorescent signal. 100 μg 1 to 2 Days
$394.90
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Immunohistochemical staining of rat brain tissue with KCNK18 polyclonal antibody  at 5 ug/mL dilution. Western blot analysis of rat brain tissue with KCNK18 polyclonal antibody  at (Lane 1) 1 and (Lane 2) 2 ug/mL dilution. 100 μg 11 to 12 Days
$356.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with KCNK18 polyclonal antibody  shows moderate cytoplasmic positivity in Purkinje cells. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-KCNK18 Antibodies

  1. Human Polyclonal KCNK18 Primary Antibody for IHC, ELISA - ABIN1031143 : Sánchez-Miguel, García-Dolores, Rosa Flores-Márquez, Delgado-Enciso, Pottosin, Dobrovinskaya: TRESK potassium channel in human T lymphoblasts. in Biochemical and biophysical research communications 2013 (PubMed)

More Antibodies against KCNK18 Interaction Partners

Human Potassium Channel Subfamily K Member 18 (KCNK18) interaction partners

  1. both human and rat TRESK contain potential anionic phospholipid binding sites (apbs) in the large cytoplasmic loop, but only the human channel is able to bind to multilamellar vesicles (MLVs), enriched with anionic phospholipids, suggesting an electrostatically mediated interaction.

  2. The presence of SCN1A mutations and absence of mutations in ATP1A2 or CACNA1A suggest that the Polish patients represent FHM type 3.

  3. This study reveals new pharmacological modulators of K2P18.1 activity useful in dissecting native K2P18.1 function

  4. Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura

  5. Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability

  6. LQLP site is a fundamental determinant of the calcium-sensitivity of human TRESK.

  7. No association was observed for three polymorphisms in the KCNK18 gene with migraine phenotype or with any haplotypes.

  8. T cell lymphoblastic leukemias/lymphomas express TRESK protein.

  9. dominant-negative mutation of human TRESK was found to be linked to migraine with aura in a large pedigree. It is hoped that future TRESK agonists may prevent or ameliorate the debilitating symptoms of migraine.

  10. A frameshift mutation in the two-pore potassium channel protein TRESK is linked to migraine pathogenesis. (Review)

  11. a role for TRESK in the pathogenesis of typical migraine with aura.

  12. single residue of TRESK was found to be glycosylated upon heterologous expression. Signals of the N-glycosylation mutants were reduced by >50% because of inadequate surface expression of the channel.

  13. TRESK is a novel two-pore domain K+ channel that may set the resting membrane potential of cells in the spinal cord

  14. TRESK is activated by increased cytoplasmic calcium concentration, calcineurin being involved in the regulation; Serine 276 was identified as the major functional target of calcineurin in TRESK

  15. TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells [TRESK-2]

  16. Because 14-3-3 proteins are ubiquitous, they are expected to control the duration of calcineurin-mediated TRESK activation in all the cell types that express the channel, depending on the phosphorylation state of serine 264.

  17. background K+ currents expressed in Jurkat cells are mediated by TRESK channels

Mouse (Murine) Potassium Channel Subfamily K Member 18 (KCNK18) interaction partners

  1. We compared the kinetics of Ba2+ block when channels were phosphorylated (inhibited) or dephosphorylated (activated) and in different mutants mimicking the two functional states. Neither the phosphorylation/dephosphorylation nor the point mutations influenced the development of Ba2+ block, suggesting that conformational changes of the bundle crossing region do not contribute to phosphorylation-dependent gating of TRESK.

  2. Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability

  3. Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies

  4. a role for TRESK in the pathogenesis of typical migraine with aura.

  5. single residue of TRESK was found to be glycosylated upon heterologous expression. Signals of the N-glycosylation mutants were reduced by >50% because of inadequate surface expression of the channel.

  6. TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells [TRESK-2]

  7. the PQIVID sequence is a docking site for calcineurin, and its occupancy is required for the calcium-dependent regulation of TRESK

  8. we found no difference in resting membrane potential between dorsal root ganglia neurones of TRESK[wild type] and TRESK knockout mice

  9. Because 14-3-3 proteins are ubiquitous, they are expected to control the duration of calcineurin-mediated TRESK activation in all the cell types that express the channel, depending on the phosphorylation state of serine 264.

KCNK18 Antigen Profile

Protein Summary

mouse homolog induces a time-independent, noninactivating K+ current

Gene names and symbols associated with KCNK18

  • potassium two pore domain channel subfamily K member 18 (KCNK18) antibody
  • potassium channel, subfamily K, member 18 (KCNK18) antibody
  • potassium channel, subfamily K, member 18 (Kcnk18) antibody
  • potassium two pore domain channel subfamily K member 18 (Kcnk18) antibody
  • Gm781 antibody
  • K2p18.1 antibody
  • MGR13 antibody
  • Tresk antibody
  • Tresk-2 antibody
  • TRESK2 antibody
  • Trik antibody

Protein level used designations for KCNK18

potassium channel, subfamily K, member 18 , potassium channel, subfamily K, member 3-like , TWIK-related individual K+ channel , TWIK-related individual potassium channel , TWIK-related spinal cord K+ channel , TWIK-related spinal cord potassium channel , potassium channel subfamily K member 18 , 2P K ion channel TRESK , two-pore-domain potassium channel TRESK , tandem-pore K+ (K(2P)) channel

GENE ID SPECIES
466212 Pan troglodytes
486907 Canis lupus familiaris
538791 Bos taurus
771448 Gallus gallus
338567 Homo sapiens
332396 Mus musculus
445371 Rattus norvegicus
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