anti-Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) Antibodies

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Additionally we are shipping KCNE2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNE2 9992 Q9Y6J6
KCNE2 171138 P63161
KCNE2 246133 Q9D808
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Top anti-KCNE2 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis in A549 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of 293T and mouse stomach cells, using KCNE2 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of KCNE2 expression in Pancreas (Mouse) Tissue Lysate ,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (31.72 KDa) . 50 μL 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of U-251MG cells, using KCNE2 antibody (ABIN6003591) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Goat Un-conjugated IHC   50 μg 11 to 16 Days
$688.29
Details
Human Rabbit Cy3 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy5 IF (p)   100 μL 14 to 21 Days
$416.90
Details

Top referenced anti-KCNE2 Antibodies

  1. Human Polyclonal KCNE2 Primary Antibody for ELISA, WB - ABIN523365 : Kanyshkova, Meuth, Bista, Liu, Ehling, Caputi, Doengi, Chetkovich, Pape, Budde: Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains. in Neurobiology of disease 2011 (PubMed)

More Antibodies against KCNE2 Interaction Partners

Human Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) interaction partners

  1. On the basis of clinical phenotype, the high allelic frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous documentation of genotype-phenotype segregation, our findings suggest that many KCNE2 variants, and perhaps all, have been erroneously designated as LQTS-causative mutations. Instead, KCNE2 variants may confer proarrhythmic susceptibility when provoked by additional envir

  2. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM.

  3. The identification of Filamin C as a novel KCNE2 ligand not only enhances current understanding of ion channel function and regulation, but also provides valuable information about possible pathways likely to be involved in long-QT syndrome pathogenesis

  4. KCNE2 has been widely studied since its role in the heart was discovered; it is association with inherited and acquired human Long QT syndrome; physiological analyses together with genetics studies have uncovered a startling array of functions for KCNE2, in the heart, stomach, thyroid and choroid plexus. [Review]

  5. Women with elevated BMI have enhanced hERG activity as a result of low beta-inhibitory protein expression, which likely contributes to weak contractions and poor labour outcomes.

  6. M54T MiRP1 mutation axecerbate drug-induced long QT syndrome and arrhythmia.

  7. The effect of KCNE2 mutations on KV7.1 was abolished in the presence of the major IKs beta-subunit KCNE1, when coexpressed in a 1:1:1 molar ratio.

  8. Mutations in KCNE2 has been shown to cause familial atrial fibrillation.

  9. The transmembrane domains (TMDs) of KCNE1 and KCNE2 were illustrated to associate with the KCNQ1 channel in different modes.

  10. study concluded that the variants in KCNQ1, KCNH2, KCNE1 and KCNE2 genes may be correlated with the occurrence of part of sudden unexplained nocturnal death syndrome cases in southern China

  11. Subjects with LQT-PM may have longer QTc intervals at rest and at peak exercise and all phases of the recovery period compared to controls. Those with homozygous SNPs (KCNE2 1%) had longer resting QTc intervals when compared to heterozygotes.

  12. Case Report: reduced expression of KCNE2 in surgically excised tissue from human gastric cancer associated with gastritis cystica profunda.

  13. KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells.

  14. The known interactions of the KCNE2 protein and the resulting functional effects, the effects of mutations in KCNE2 and their clinical role are discussed. [review]

  15. KCNE2 can modulate its partner channel function not only by altering channel conductance and/or gating kinetics, but also by affecting protein stability.

  16. Backbone assignments of most MiRP1 residues were achieved through a series of triple resonance NMR experiments.

  17. Results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia.

  18. KCNE2 plays a role in normal function of native I(to) channel complex in human heart, M54T and I57T variants lead to gain of function of I(to), contributing to generating potential arrhythmogeneity and pathogenesis for inherited fatal rhythm disorders.

  19. The accelerated inactivation time course of HERG/MiRP1(V65M) channels may decrease I(Kr) current density of myocardial cells, thereby impairing the ability of myocytes to repolarize in response to sudden membrane depolarizations such as extrasystoles.

  20. KCNE2, by modulating I(f) or I(h) currents, might thus contribute to the electrophysiological diversity of known pacemaking currents in the heart and brain

Mouse (Murine) Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2) interaction partners

  1. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM.

  2. Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury

  3. The data establish causality for the first example of ion channel-linked atherosclerosis, and demonstrate that the severity of Kcne2-linked cardiac arrhythmias is strongly diet-dependent.

  4. Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration.

  5. Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia.

  6. KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability.

  7. The Kcne2 Deletion suggest that a more holistic view of the pathogenesis of monogenic cardiac arrhythmias could provide a clearer picture of the mechanisms underlying sudden cardiac dealth.

  8. KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells.

  9. Loss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop.

  10. KCNE2 influences blood-CSF anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium.

  11. The results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia.

  12. KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function.

  13. Targeted disruption of kcne2 has revealed a novel cardiac partner for MiRP1, a novel role for MiRPs in alpha subunit targeting in vivo, and a role for MiRP1 in murine ventricular repolarization with parallels to that proposed for the human heart.

  14. Cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy.

  15. we describe the transcription profiles of the four HCN genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse.

  16. KCNE2 serves as a regulatory beta-subunit of Hyperpolarization-activated cation channels

  17. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.

KCNE2 Antigen Profile

Protein Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.

Gene names and symbols associated with KCNE2

  • potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2) antibody
  • potassium voltage-gated channel subfamily E regulatory subunit 2 (Kcne2) antibody
  • potassium voltage-gated channel, Isk-related subfamily, gene 2 (Kcne2) antibody
  • 2200002I16Rik antibody
  • ATFB4 antibody
  • AW048273 antibody
  • LQT5 antibody
  • LQT6 antibody
  • MiRP1 antibody

Protein level used designations for KCNE2

cardiac voltage-gated potassium channel accessory subunit 2 , minK-related peptide 1 , minK-related peptide-1 , minimum potassium ion channel-related peptide 1 , potassium channel subunit beta MiRP1 , potassium channel subunit, MiRP1 , potassium voltage-gated channel subfamily E member 2 , voltage-gated K+ channel subunit MIRP1 , potassium voltage-gated channel, Isk-related subfamily, gene 2 , MinK-related peptide 1 , potassium channel beta subunit , K+/pacemaker channel beta subunit mirp1 , minimum potassium ion channel related peptide 1

GENE ID SPECIES
9992 Homo sapiens
171138 Rattus norvegicus
403471 Canis lupus familiaris
768025 Bos taurus
100008804 Oryctolagus cuniculus
246133 Mus musculus
100725255 Cavia porcellus
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