Pre-B-Cell Leukemia Homeobox Protein 1 Proteins (PBX1)

Human Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

1. an oncogenic role for the protein lysine methyltransferase SETDB2 in leukemia pathogenesis. It is overexpressed in pre-BCR(+) ALL and required for their maintenance in vitro and in vivo. SETDB2 expression is maintained as a direct target gene of the chimeric transcription factor E2A-PBX1 in a subset of ALL and suppresses expression of the cell-cycle inhibitor CDKN2C through histone H3K9 tri-methylation.

2. Most adult ALL patients with t (1; 19) (E2A-PBX1) is Pre B-Adult Acute Lymphoblastic Leukemia by Immunophenotyping

3. Our results indicate an important influence of the neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in obsessive-compulsive disorder susceptibility

4. PBX1 plays an oncogenic role in clear cell renal carcinoma via JAK2/STAT3 pathway

5. B-cell acute lymphoblastic leukemia patients with positive E2A-PBX1 fusion expression after transplant will have a poor prognosis.

6. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation.

7. The sequence variants in our cases included missense substitutions adjacent to the PBX1 homeodomain (p.Arg184Pro, p.Met224Lys, and p.Arg227Pro) or within the homeodomain (p.Arg234Pro, and p.Arg235Gln), whereas p.Ser262Glnfs*2, and p.Arg288* yielded truncated PBX1 proteins.

8. PBX1 is one of the determinants in the Cx32 promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.

9. A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma

10. PBX1 haploinsufficiency leads to syndromic CAKUT.

11. This is the first time the protein partners of either E2A-PBX1 or HOXA9 oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 might indicate a novel function for HOX proteins independent of their transcriptional activity.

12. involved in monogenic anomalies of kidney and urinary tract

13. these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.

14. the PBX1 binding motif at its promoter acted to positively regulate STAT3 transcription.

15. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function

16. Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 levels increases damage by oxidative stress in human midbrain cells.

17. PBX1 overexpression in MCF10A cells up-regulated most LiMe genes.

18. results indicate that E2A-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A fusion genes to develop B-lineage ALL

19. Review of the role of the E2A-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.

20. This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia.

Zebrafish Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

1. findings suggest that pbx1 may be required during the late stage of swim bladder development

Mouse (Murine) Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

1. mouse PBX1 and PBX2 have roles in pulmonary vascular adaptation to birth

2. a mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes

3. uc.40 may play an important role during the differentiation of P19 cells by regulation of PBX1 to promote proliferation and inhibit apoptosis.

4. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation.

5. Pbx-dependent Epithelial-mesenchymal transition programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1.

6. MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber.

7. results indicate Pbx genes act in parallel genetic pathways to orchestrate neuronal subtype differentiation, connectivity, and organization. I

8. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.

9. PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2.

10. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function

11. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 axis

12. non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis

13. Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.

14. Thus, PTBP1 controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.

15. this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.

16. Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.

17. Results thus show how Pbx1 controls Fgf10 in the developing lung.

18. Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.

19. These results demonstrate a role for Pbx1 in restraining myeloid maturation while maintaining lymphoid potential to appropriately regulate progenitor reservoirs.

20. The Systemic Lupus Erythematosus-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.

Xenopus laevis Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

1. Pbx transcription factor plays a crucial role in Xenopus lens development

2. These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.